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Anti-HSPA5 Monoclonal Antibody (14A2)
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Product Description:The Anti-HSPA5 antibody is a mouse monoclonal antibody recommended for use in western blot, flow cytometry, immunohistochemistry, ELISA, inhibition and other applications. This antibody specifically targets HSPA5 and demonstrates reactivity with human, mouse.Applications:Western Blot, Flow Cytometry, Immunohistochemistry, Enzyme-Linked Immunosorbent Assay, InhibitionTarget:HSPA5Target Species:HumanSpecificity:This antibody reacts with human HSPA5.Immunogen:Human HSPA5 proteinClonality:MonoclonalClone ID:14A2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-HSPA5 Monoclonal Antibody (14A2) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
HSPA5
Protein Name
Endoplasmic reticulum chaperone BiP
Introduction
The protein encoded by this gene is a member of the heat shock protein 70 (HSP70) family. This protein localizes to the lumen of the endoplasmic reticulum (ER) where it operates as a typical HSP70 chaperone involved in the folding and assembly of proteins in the ER and is a master regulator of ER homeostasis. During cellular stress, as during viral infection or tumorogenesis, this protein interacts with the transmembrane stress sensor proteins PERK (protein kinase R-like endoplasmic reticulum kinase), IRE1 (inositol-requiring kinase 1), and ATF6 (activating transcription factor 6) where it acts as a repressor of the unfolded protein response (UPR) and also plays a role in cellular apoptosis and senescence. Elevated expression and atypical translocation of this protein to the cell surface has been reported in viral infections and some types of cancer cells. At the cell surface this protein may facilitate viral attachment and entry to host cells. This gene is a therapeutic target for the treatment of coronavirus diseases and chemoresistant cancers.
Alternative Names
BIP; MIF2; GRP78; HEL-S-89n; endoplasmic reticulum chaperone BiP; 78 kDa glucose-regulated protein; HSP70 family protein 5
Gene ID
UniProt
Subcellular Location
Endoplasmic reticulum lumen
Cell Line Specificity
Low cancer specificity
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