Anti-HSD11B1 Monoclonal Antibody (A-16B5)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C955	Anti-HSD11B1 Antibody (A-16B5)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C955

Anti-HSD11B1 Antibody (A-16B5)

Mouse IgG

None

$460

Add

Anti-HSD11B1 Monoclonal Antibody (A-16B5)
- Product Description:
  
  The Anti-HSD11B1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human HSD11B1.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  HSD11B1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Hydroxysteroid 11-Beta Dehydrogenase 1 (HSD11B1).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  A-16B5
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-HSD11B1 Monoclonal Antibody (A-16B5) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

11-beta-hydroxysteroid dehydrogenase 1

Introduction

The protein encoded by this gene is a microsomal enzyme that catalyzes the conversion of the stress hormone cortisol to the inactive metabolite cortisone. In addition, the encoded protein can catalyze the reverse reaction, the conversion of cortisone to cortisol. Too much cortisol can lead to central obesity, and a particular variation in this gene has been associated with obesity and insulin resistance in children. Mutations in this gene and H6PD (hexose-6-phosphate dehydrogenase (glucose 1-dehydrogenase)) are the cause of cortisone reductase deficiency. Alternate splicing results in multiple transcript variants encoding the same protein.

Alternative Names

11-DH; 11-beta-HSD1; CORTRD2; HDL; HSD11; HSD11B; HSD11L; SDR26C1

Gene ID

3290

UniProt

P28845

Related Disease

Cortisone reductase deficiency 2 (CORTRD2)

Subcellular Location

Endoplasmic reticulum membrane

Cell Line Specificity

Cancer enhanced