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Anti-HIV-1 gp120 Monoclonal Antibody (YZ23)
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Product Description:The antibody is a mouse monoclonal antibody recommended for use in neutralization, enzyme-linked immunosorbent assay and other applications. This antibody specifically targets HIV-1 gp120.Applications:Neutralization, Enzyme-Linked Immunosorbent AssayTarget:HIV-1 gp120Specificity:This antibody reacts with HIV-1 gp120.Clonality:MonoclonalClone ID:YZ23Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-HIV-1 gp120 Monoclonal Antibody (YZ23) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
env
Protein Name
Envelope glycoprotein gp160
Introduction
The Env gene codes for the gp160 protein which forms a homotrimer, and is cleaved into gp120 and gp41 by the host cell protease, Furin. To form an active fusion protein, gp120 and gp41 polypeptides remain non-covalently bound together, but this interaction is often not stable, leading to shed, soluble gp120 and membrane-bound, gp41 'stumps'. Separately, cleavage by furin is inefficient, and virions often are released with inactive, uncleaved gp160. Because of the high prevalence of these inactive forms, the immune system often produces antibodies which target inactive Env, rather than active forms of the envelope protein.
Alternative Names
HIV-1 gp120; Human immunodeficiency virus gp120; gp120
Gene ID
UniProt
Subcellular Location
Virion membrane
Function
Envelope glycoprotein gp160: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.
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