Anti-HIV-1 gp120 Monoclonal Antibody

Subcat	Description	Isotype	Conjugate	Price
ASPC1156	Anti-HIV-1 gp120 Antibody	Human IgG1, Lambda	None	$460	Add
ASPC1156-A	Anti-HIV-1 gp120 Antibody, APC	Human IgG1, Lambda	APC	$980	Add
ASPC1156-B	Anti-HIV-1 gp120 Antibody, Biotin	Human IgG1, Lambda	Biotin	$680	Add
ASPC1156-H	Anti-HIV-1 gp120 Antibody, HRP	Human IgG1, Lambda	HRP	$600	Add
ASPC1156-P	Anti-HIV-1 gp120 Antibody, PE	Human IgG1, Lambda	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1156

Anti-HIV-1 gp120 Antibody

Human IgG1, Lambda

None

$460

Add

ASPC1156-A

Anti-HIV-1 gp120 Antibody, APC

Human IgG1, Lambda

APC

$980

Add

ASPC1156-B

Anti-HIV-1 gp120 Antibody, Biotin

Human IgG1, Lambda

Biotin

$680

Add

ASPC1156-H

Anti-HIV-1 gp120 Antibody, HRP

Human IgG1, Lambda

HRP

$600

Add

ASPC1156-P

Anti-HIV-1 gp120 Antibody, PE

Human IgG1, Lambda

$1,180

Add

Anti-HIV-1 gp120 Monoclonal Antibody
- Product Description:
  
  The Anti-HIV-1 gp120 antibody is a human monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, neutralization, blocking and other applications. This antibody specifically recognizes HIV-1 gp120.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Neutralization, Blocking
  
  Source:
  
  Human
  
  Target:
  
  HIV-1 gp120
  
  Specificity:
  
  This antibody reacts with HIV-1 gp120.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-HIV-1 gp120 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

env

Protein Name

Envelope glycoprotein gp160

Introduction

The Env gene codes for the gp160 protein which forms a homotrimer, and is cleaved into gp120 and gp41 by the host cell protease, Furin. To form an active fusion protein, gp120 and gp41 polypeptides remain non-covalently bound together, but this interaction is often not stable, leading to shed, soluble gp120 and membrane-bound, gp41 'stumps'. Separately, cleavage by furin is inefficient, and virions often are released with inactive, uncleaved gp160. Because of the high prevalence of these inactive forms, the immune system often produces antibodies which target inactive Env, rather than active forms of the envelope protein.

Alternative Names

HIV-1 gp120; Human immunodeficiency virus gp120; gp120

UniProt

P03377

Subcellular Location

Virion membrane

Function

Envelope glycoprotein gp160: Oligomerizes in the host endoplasmic reticulum into predominantly trimers. In a second time, gp160 transits in the host Golgi, where glycosylation is completed. The precursor is then proteolytically cleaved in the trans-Golgi and thereby activated by cellular furin or furin-like proteases to produce gp120 and gp41.

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