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Anti-HBEGF Monoclonal Antibody (KM3566)
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Product Description:The anti-HBEGF antibody is a mouse monoclonal antibody recommended for Neutralization, Western Blot, Enzyme-Linked Immunosorbent Assay, Flow Cytometry. This antibody specifically targets HBEGF and demonstrates reactivity with human.Applications:Neutralization, Western Blot, Enzyme-Linked Immunosorbent Assay, Flow CytometryTarget:HBEGFTarget Species:HumanSpecificity:This antibody reacts with human HBEGF.Clonality:MonoclonalClone ID:KM3566Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.Form:LiquidEndotoxin:Please contact us for more information.Preservative:Azide freeStabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-HBEGF Monoclonal Antibody (KM3566) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
HBEGF
Protein Name
Proheparin-Binding Egf-Like Growth Factor
Introduction
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor
Alternative Names
HBEGF; Heparin-Binding Epidermal Growth Factor; HEGFL; DTSF; DTR; Heparin-Binding EGF-Like Growth Factor; DTS; Proheparin-Binding EGF-Like Growth Factor; Diphtheria Toxin Receptor (Heparin-Binding EGF-Like Growth Factor)
Gene ID
UniProt
Subcellular Location
Cell membrane
Membrane
Secreted
Membrane
Secreted
Function
Growth factor that mediates its effects via EGFR, ERBB2 and ERBB4. Required for normal cardiac valve formation and normal heart function. Promotes smooth muscle cell proliferation. May be involved in macrophage-mediated cellular proliferation. It is mitogenic for fibroblasts, but not endothelial cells. It is able to bind EGF receptor/EGFR with higher affinity than EGF itself and is a far more potent mitogen for smooth muscle cells than EGF. Also acts as a diphtheria toxin receptor.
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