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Anti-HAVCR2 Monoclonal Antibody (mab15)
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Product Description:MAb15 is a monoclonal antibody that specifically binds to human TIM-3 (T-cell immunoglobulin and mucin-domain containing-3), also known as HAVCR2 (Hepatitis A virus cellular receptor 2). TIM-3 is a critical immune checkpoint receptor expressed on various immune cells. This antibody inhibits the interaction between TIM-3 and LILRB2.Applications:Functional Assay, Inhibition, Enzyme-Linked Immunosorbent Assay, Flow CytometrySource:MouseTarget:HAVCR2Specificity:Human TIM-3Immunogen:Human and mouse TIM3 proteinClonality:MonoclonalClone ID:mab15Isotype:Mouse IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-HAVCR2 Monoclonal Antibody (mab15) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
HAVCR2
Protein Name
Hepatitis A virus cellular receptor 2
Molecular Family
CD Molecules, Immune Checkpoint Receptors
Introduction
The protein encoded by this gene belongs to the immunoglobulin superfamily, and TIM family of proteins. CD4-positive T helper lymphocytes can be divided into types 1 (Th1) and 2 (Th2) on the basis of their cytokine secretion patterns. Th1 cells are involved in cell-mediated immunity to intracellular pathogens and delayed-type hypersensitivity reactions, whereas, Th2 cells are involved in the control of extracellular helminthic infections and the promotion of atopic and allergic diseases. This protein is a Th1-specific cell surface protein that regulates macrophage activation, and inhibits Th1-mediated auto- and alloimmune responses, and promotes immunological tolerance.
Alternative Names
TIM3; CD366; KIM-3; SPTCL; TIMD3; Tim-3; TIMD-3; HAVcr-2
Gene ID
UniProt
Related Disease
T-cell lymphoma, subcutaneous panniculitis-like (SPTCL)
Tissue Specificity
Expressed in T-helper type 1 (Th1) lymphocytes. Expressed on regulatory T (Treg) cells after TCR stimulation. Expressed in dendritic cells and natural killer (NK) cells. Expressed in epithelial tissues. Expression is increased on CD4+ and CD8+ T-cells in chronic hepatitis C virus (HCV) infection. In progressive HIV-1 infection, expression is up-regulated on HIV-1-specific CD8 T-cells.
Cell Type
Dendritic cells, Monocytes, T cells, Th1, Tregs
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