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Anti-GREM1 Monoclonal Antibody (13C2)
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Product Description:The Anti-GREM1 antibody is a human monoclonal antibody recommended for use in ELISA, neutralization and other applications. This antibody specifically targets GREM1 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, NeutralizationTarget:GREM1Target Species:HumanSpecificity:This antibody reacts with human GREM1.Immunogen:Human Gremlin 1 proteinClonality:MonoclonalClone ID:13C2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-GREM1 Monoclonal Antibody (13C2) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
GREM1
Protein Name
Gremlin-1
Introduction
This gene encodes a member of the BMP (bone morphogenic protein) antagonist family. Like BMPs, BMP antagonists contain cystine knots and typically form homo- and heterodimers. The CAN (cerberus and dan) subfamily of BMP antagonists, to which this gene belongs, is characterized by a C-terminal cystine knot with an eight-membered ring. The antagonistic effect of the secreted glycosylated protein encoded by this gene is likely due to its direct binding to BMP proteins. As an antagonist of BMP, this gene may play a role in regulating organogenesis, body patterning, and tissue differentiation. In mouse, this protein has been shown to relay the sonic hedgehog (SHH) signal from the polarizing region to the apical ectodermal ridge during limb bud outgrowth. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
GREM1; gremlin 1; DAN family BMP antagonist; DRM; HMPS; MPSH; PIG2; CRAC1; CRCS4; DAND2; HMPS1; IHG-2; DUP15q; C15DUPq; GREMLIN; CKTSF1B1
Gene ID
UniProt
Related Disease
Polyposis syndrome, mixed hereditary 1 (HMPS1)
Subcellular Location
Secreted
Cell Line Specificity
Cancer enhanced
Function
Cytokine that may play an important role during carcinogenesis and metanephric kidney organogenesis, as a BMP antagonist required for early limb outgrowth and patterning in maintaining the FGF4-SHH feedback loop. Down-regulates the BMP4 signaling in a dose-dependent manner (By similarity).
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