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Anti-GP1BA Monoclonal Antibody (A-14H9)
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Product Description:The Anti-GP1BA antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human GP1BA.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:GP1BATarget Species:HumanSpecificity:This antibody reacts with human Glycoprotein Ib Platelet Alpha Subunit (GP1BA).Immunogen:Recombinant CD42b proteinClonality:MonoclonalClone ID:A-14H9Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.05% Proclin 300Shipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-GP1BA Monoclonal Antibody (A-14H9) Applications
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Recommended Dilution:Western Blot: 0.01-2 µg/mL
Immunohistochemistry: 5-20 µg/mL
Immunocytochemistry: 5-20 µg/mLNote:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Platelet glycoprotein Ib alpha chain
Introduction
Glycoprotein Ib (GP Ib) is a platelet surface membrane glycoprotein composed of a heterodimer, an alpha chain and a beta chain, that is linked by disulfide bonds. The Gp Ib functions as a receptor for von Willebrand factor (VWF). The complete receptor complex includes noncovalent association of the alpha and beta subunits with platelet glycoprotein IX and platelet glycoprotein V. The binding of the GP Ib-IX-V complex to VWF facilitates initial platelet adhesion to vascular subendothelium after vascular injury, and also initiates signaling events within the platelet that lead to enhanced platelet activation, thrombosis, and hemostasis. This gene encodes the alpha subunit. Mutations in this gene result in Bernard-Soulier syndromes and platelet-type von Willebrand disease. The coding region of this gene is known to contain a polymophic variable number tandem repeat (VNTR) domain that is associated with susceptibility to nonarteritic anterior ischemic optic neuropathy.
Alternative Names
BDPLT1; BDPLT3; BSS; CD42B; CD42b-alpha; DBPLT3; GP1B; GPIbA; GPIbalpha; VWDP
Gene ID
UniProt
Related Disease
Non-arteritic anterior ischemic optic neuropathy (NAION)
Subcellular Location
Membrane; Single-pass type I membrane protein.
Cell Line Specificity
Low cancer specificity
Function
GP-Ib, a surface membrane protein of platelets, participates in the formation of platelet plugs by binding to the A1 domain of vWF, which is already bound to the subendothelium.
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