Anti-GHRL Monoclonal Antibody (1621)

Subcat	Description	Isotype	Conjugate	Price
ASPC1101	Anti-GHRL Antibody (1621)	Mouse IgG1, Kappa	None	$460	Add
ASPC1101-A	Anti-GHRL Antibody (1621), APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1101-B	Anti-GHRL Antibody (1621), Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1101-H	Anti-GHRL Antibody (1621), HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1101-P	Anti-GHRL Antibody (1621), PE	Mouse IgG1, Kappa	PE	$1,180	Add

Anti-GHRL Monoclonal Antibody (1621)
- Product Description:
  
  The Anti-GHRL antibody is a mouse monoclonal antibody recommended for use in enzyme-linked immunosorbent assay, surface plasmon resonance and other applications. This antibody specifically targets GHRL and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Surface Plasmon Resonance
  
  Source:
  
  Mouse
  
  Target:
  
  GHRL
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human GHRL.
  
  Immunogen:
  
  Human ghrelin with acylation at the histidine position 9.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1621
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-GHRL Monoclonal Antibody (1621) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

GHRL

Protein Name

Appetite-regulating hormone

Introduction

This gene encodes the ghrelin-obestatin preproprotein that is cleaved to yield two peptides, ghrelin and obestatin. Ghrelin is a powerful appetite stimulant and plays an important role in energy homeostasis. Its secretion is initiated when the stomach is empty, whereupon it binds to the growth hormone secretagogue receptor in the hypothalamus which results in the secretion of growth hormone (somatotropin). Ghrelin is thought to regulate multiple activities, including hunger, reward perception via the mesolimbic pathway, gastric acid secretion, gastrointestinal motility, and pancreatic glucose-stimulated insulin secretion. It was initially proposed that obestatin plays an opposing role to ghrelin by promoting satiety and thus decreasing food intake, but this action is still debated. Recent reports suggest multiple metabolic roles for obestatin, including regulating adipocyte function and glucose metabolism. Alternative splicing results in multiple transcript variants. In addition, antisense transcripts for this gene have been identified and may potentially regulate ghrelin-obestatin preproprotein expression.

Alternative Names

MTLRP

Gene ID

51738

UniProt

Q9UBU3

Subcellular Location

Secreted.

Tissue Specificity

Highest level in stomach. All forms are found in serum as well. Other tissues compensate for the loss of ghrelin synthesis in the stomach following gastrectomy.

Cell Line Specificity

Low cancer specificity

Function

Ghrelin-27: Ghrelin is the ligand for growth hormone secretagogue receptor type 1 (GHSR). Induces the release of growth hormone from the pituitary. Has an appetite-stimulating effect, induces adiposity and stimulates gastric acid secretion. Involved in growth regulation.

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