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Anti-FOLR2 Monoclonal Antibody (7C9)
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Product Description:The Anti-FOLR2 antibody is a mouse monoclonal antibody recommended for use in ELISA, western blot and other applications. This antibody specifically targets FOLR2 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Western BlotTarget:FOLR2Target Species:HumanSpecificity:This antibody reacts with human FOLR2.Immunogen:Human FOLR2 proteinClonality:MonoclonalClone ID:7C9Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-FOLR2 Monoclonal Antibody (7C9) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
FOLR2
Protein Name
Folate receptor beta
Introduction
The protein encoded by this gene is a member of the folate receptor (FOLR) family, and these genes exist in a cluster on chromosome 11. Members of this gene family have a high affinity for folic acid and for several reduced folic acid derivatives, and they mediate delivery of 5-methyltetrahydrofolate to the interior of cells. This protein has a 68% and 79% sequence homology with the FOLR1 and FOLR3 proteins, respectively. Although this protein was originally thought to be specific to placenta, it can also exist in other tissues, and it may play a role in the transport of methotrexate in synovial macrophages in rheumatoid arthritis patients. Multiple transcript variants that encode the same protein have been found for this gene.
Alternative Names
FOLR2; folate receptor 2 (fetal); FBP; FR-P3; FR-BETA; BETA-HFR; FBP/PL-1; folate receptor beta; folate receptor; beta; folate receptor; fetal/placental; placental folate-binding protein; folate-binding protein; fetal/placental
Gene ID
UniProt
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor. Secreted
Tissue Specificity
Expressed in placenta and hematopoietic cells. Expression is increased in malignant tissues.
Cell Line Specificity
Group enriched
Function
Binds to folate and reduced folic acid derivatives and mediates delivery of 5-methyltetrahydrofolate and folate analogs into the interior of cells. Has high affinity for folate and folic acid analogs at neutral pH. Exposure to slightly acidic pH after receptor endocytosis triggers a conformation change that strongly reduces its affinity for folates and mediates their release.
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