Anti-FOLH1 Monoclonal Antibody (9H6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC670	Anti-FOLH1 Antibody (9H6)	Human IgG1, Lambda	None	$460	In stock	Add
ASPC670-P	Anti-FOLH1 Antibody (9H6), PE	Human IgG1, Lambda	PE	$1,180	2-3 weeks	Add
ASPC670-A	Anti-FOLH1 Antibody (9H6), APC	Human IgG1, Lambda	APC	$980	2-3 weeks	Add
ASPC670-H	Anti-FOLH1 Antibody (9H6), HRP	Human IgG1, Lambda	HRP	$600	2-3 weeks	Add
ASPC670-B	Anti-FOLH1 Antibody (9H6), Biotin	Human IgG1, Lambda	Biotin	$680	2-3 weeks	Add

Anti-FOLH1 Monoclonal Antibody (9H6)
- Product Description:
  
  The Anti-FOLH1 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, functional assay, blocking and other applications. This antibody specifically targets FOLH1 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Functional Assay, Blocking
  
  Target:
  
  FOLH1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human FOLH1.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  9H6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-FOLH1 Monoclonal Antibody (9H6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

FOLH1

Protein Name

Glutamate carboxypeptidase 2

Introduction

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Alternative Names

PSM; FGCP; FOLH; GCP2; PSMA; mGCP; GCPII; NAALAD1; Folate Hydrolase 1

Gene ID

2346

UniProt

Q04609

Subcellular Location

Cell membrane

Cell Line Specificity

Group enriched

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression. Also exhibits a dipeptidyl-peptidase IV type activity. In vitro, cleaves Gly-Pro-AMC.

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