Anti-FOLH1 Monoclonal Antibody (7F12)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC093	Anti-FOLH1 Antibody (7F12)	Human IgG1, Kappa		None	$460	In stock	Add
ASPC093-P	Anti-FOLH1 Antibody (7F12), PE	Human IgG1, Kappa		PE	$1,180	2-3 weeks	Add
ASPC093-A	Anti-FOLH1 Antibody (7F12), APC	Human IgG1, Kappa		APC	$980	2-3 weeks	Add
ASPC093-H	Anti-FOLH1 Antibody (7F12), HRP	Human IgG1, Kappa		HRP	$600	2-3 weeks	Add
ASPC093-B	Anti-FOLH1 Antibody (7F12), Biotin	Human IgG1, Kappa		Biotin	$680	2-3 weeks	Add
ASPC093-4	Anti-FOLH1 Antibody (7F12), Fc Silenced	Human IgG1, Kappa	Fc Silenced	None	$980	4-6 weeks	Add

Anti-FOLH1 Monoclonal Antibody (7F12)
- Product Description:
  
  7F12 is a monoclonal antibody that recognizes a conformational epitope on the human Prostate-Specific Membrane Antigen (PSMA).
  
  Applications:
  
  Immunoprecipitation, Enzyme-Linked Immunosorbent Assay
  
  Source:
  
  Mouse
  
  Target:
  
  FOLH1
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human PSMA
  
  Immunogen:
  
  Cell membranes and purified prostate-specific membrane antigen (PSMA) from LNCaP cells.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  7F12
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-FOLH1 Monoclonal Antibody (7F12) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

FOLH1

Protein Name

Glutamate carboxypeptidase 2

Introduction

This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms.

Alternative Names

Folate Hydrolase 1; N-Acetylated-Alpha-Linked Acidic Dipeptidase I; Pteroylpoly-Gamma-Glutamate Carboxypeptidase; Folylpoly-Gamma-Glutamate Carboxypeptidase; Cell Growth-Inhibiting Gene 27 Protein; Membrane Glutamate Carboxypeptidase; Glutamate Carboxypeptidase II; Glutamate Carboxypeptidase 2; Glutamate Carboxylase II; EC 3.4.17.21; NAALADase I; NAALAD1; GCPII

Gene ID

2346

UniProt

Q04609

Tissue Specificity

Highly expressed in prostate epithelium. Detected in urinary bladder, kidney, testis, ovary, fallopian tube, breast, adrenal gland, liver, esophagus, stomach, small intestine, colon and brain (at protein level). Detected in the small intestine, brain, kidney, liver, spleen, colon, trachea, spinal cord and the capillary endothelium of a variety of tumors. Expressed specifically in jejunum brush border membranes. In the brain, highly expressed in the ventral striatum and brain stem. Also expressed in fetal liver and kidney. Isoform PSMA' is the most abundant form in normal prostate. Isoform PSMA-1 is the most abundant form in primary prostate tumors. Isoform PSMA-3 is also found in normal prostate as well as in brain and liver. Isoform PSMA-9 is specifically expressed in prostate cancer.

Cell Type

Epithelial cells

Function

Has both folate hydrolase and N-acetylated-alpha-linked-acidic dipeptidase (NAALADase) activity. Has a preference for tri-alpha-glutamate peptides. In the intestine, required for the uptake of folate. In the brain, modulates excitatory neurotransmission through the hydrolysis of the neuropeptide, N-aceylaspartylglutamate (NAAG), thereby releasing glutamate. Involved in prostate tumor progression.

Customer Reviews

There are no reviews for Product Name.

Submit a review and receive an Amazon gift card.

Publications

There are no publications for Product Name.

If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward