Anti-FLT3 Monoclonal Antibody (NC7)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC106	Anti-FLT3 Antibody (NC7)	Human IgG1, Kappa		None	$460	In stock	Add
ASPC106-P	Anti-FLT3 Antibody (NC7), PE	Human IgG1, Kappa		PE	$1,180	2-3 weeks	Add
ASPC106-A	Anti-FLT3 Antibody (NC7), APC	Human IgG1, Kappa		APC	$980	2-3 weeks	Add
ASPC106-H	Anti-FLT3 Antibody (NC7), HRP	Human IgG1, Kappa		HRP	$600	2-3 weeks	Add
ASPC106-B	Anti-FLT3 Antibody (NC7), Biotin	Human IgG1, Kappa		Biotin	$680	2-3 weeks	Add
ASPC106-4	Anti-FLT3 Antibody (NC7), Fc Silenced	Human IgG1, Kappa	Fc Silenced	None	$980	4-6 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC106

Anti-FLT3 Antibody (NC7)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC106-P

Anti-FLT3 Antibody (NC7), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC106-A

Anti-FLT3 Antibody (NC7), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC106-H

Anti-FLT3 Antibody (NC7), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC106-B

Anti-FLT3 Antibody (NC7), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

ASPC106-4

Anti-FLT3 Antibody (NC7), Fc Silenced

Human IgG1, Kappa

Fc Silenced

None

$980

4-6 weeks

Add

Anti-FLT3 Monoclonal Antibody (NC7)
- Product Description:
  
  The NC7 antibody is a monoclonal antibody that specifically targets an epitope within Domain 5 of human Fms-like tyrosine kinase 3 (FLT3), a receptor tyrosine kinase that plays a crucial role in the regulation of hematopoiesis, particularly in the development of early hematopoietic progenitor cells.
  
  Applications:
  
  Surface Plasmon Resonance, Enzyme-Linked Immunosorbent Assay, Flow Cytometry
  
  Source:
  
  Human
  
  Target:
  
  FLT3
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human FLT3 domain D5
  
  Immunogen:
  
  Human FLT3 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  NC7
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-FLT3 Monoclonal Antibody (NC7) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

FLT3

Protein Name

Receptor-type tyrosine-protein kinase FLT3

Molecular Family

CD Molecules, Cytokine/Chemokine Receptors

Introduction

This gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. This receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.

Alternative Names

Fms Related Tyrosine Kinase 3; Stem Cell Tyrosine Kinase 1; Fms-Like Tyrosine Kinase 3; FL Cytokine Receptor; CD135 Antigen; EC 2.7.10.1; CD135; FLK-2; STK1; FLK2

Gene ID

2322

UniProt

P36888

Subcellular Location

Endoplasmic reticulum

Tissue Specificity

Detected in bone marrow, in hematopoietic stem cells, in myeloid progenitor cells and in granulocyte/macrophage progenitor cells (at protein level). Detected in bone marrow, liver, thymus, spleen and lymph node, and at low levels in kidney and pancreas. Highly expressed in T-cell leukemia.

Cell Type

B cells, Hematopoietic stem and progenitors, Leukemia, Thymocytes

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