Anti-FLNB Monoclonal Antibody (3F10)

Subcat	Description	Isotype	Conjugate	Price
ASPC1506	Anti-FLNB Antibody (3F10)	Mouse IgG2a, Kappa	None	$530	Add
ASPC1506-A	Anti-FLNB Antibody (3F10), APC	Mouse IgG2a, Kappa	APC	$1,030	Add
ASPC1506-B	Anti-FLNB Antibody (3F10), Biotin	Mouse IgG2a, Kappa	Biotin	$760	Add
ASPC1506-H	Anti-FLNB Antibody (3F10), HRP	Mouse IgG2a, Kappa	HRP	$680	Add
ASPC1506-P	Anti-FLNB Antibody (3F10), PE	Mouse IgG2a, Kappa	PE	$1,280	Add

Anti-FLNB Monoclonal Antibody (3F10)
- Product Description:
  
  The Anti-FLNB antibody is a mouse monoclonal antibody recommended for enzyme-linked immunosorbent assay and other applications. This antibody specifically targets FLNB and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  FLNB
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human FLNB.
  
  Immunogen:
  
  Human FLNB.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  3F10
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-FLNB Monoclonal Antibody (3F10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

FLNB

Protein Name

Filamin-B

Introduction

This gene encodes a member of the filamin family. The encoded protein interacts with glycoprotein Ib alpha as part of the process to repair vascular injuries. The platelet glycoprotein Ib complex includes glycoprotein Ib alpha, and it binds the actin cytoskeleton. Mutations in this gene have been found in several conditions: atelosteogenesis type 1 and type 3; boomerang dysplasia; autosomal dominant Larsen syndrome; and spondylocarpotarsal synostosis syndrome. Multiple alternatively spliced transcript variants that encode different protein isoforms have been described for this gene.

Alternative Names

ABP-278; ABP-280; AOI; FH1; FLN-B; FLN1L; LRS1; SCT; TABP; TAP

Gene ID

2317

UniProt

O75369

Tissue Specificity

Ubiquitous. Isoform 1 and isoform 2 are expressed in placenta, bone marrow, brain, umbilical vein endothelial cells (HUVEC), retina and skeletal muscle. Isoform 1 is predominantly expressed in prostate, uterus, liver, thyroid, stomach, lymph node, small intestine, spleen, skeletal muscle, kidney, placenta, pancreas, heart, lung, platelets, endothelial cells, megakaryocytic and erythroleukemic cell lines. Isoform 2 is predominantly expressed in spinal cord, platelet and Daudi cells. Also expressed in thyroid adenoma, neurofibrillary tangles (NFT), senile plaques in the hippocampus and cerebral cortex in Alzheimer disease (AD). Isoform 3 and isoform 6 are expressed predominantly in lung, heart, skeletal muscle, testis, spleen, thymus and leukocytes. Isoform 4 and isoform 5 are expressed in heart.

Cell Line Specificity

Low cancer specificity

Function

Connects cell membrane constituents to the actin cytoskeleton. May promote orthogonal branching of actin filaments and links actin filaments to membrane glycoproteins. Anchors various transmembrane proteins to the actin cytoskeleton. Interaction with FLNA may allow neuroblast migration from the ventricular zone into the cortical plate. Various interactions and localizations of isoforms affect myotube morphology and myogenesis. Isoform 6 accelerates muscle differentiation in vitro.

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