Anti-FGFR4 Monoclonal Antibody (4C2)

Anti-FGFR4 Monoclonal Antibody (4C2)

Cat No: ASPC551

Summary
Host Species:
Mouse
Species Reactivity:
Human
Applications:
Enzyme-Linked Immunosorbent Assay, Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
Clone ID:
4C2
Clonality:
Monoclonal

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Product Information
Subcat Description Isotype Antibody Modification Conjugate Size Price Quantity
ASPC551 Anti-FGFR4 Antibody (4C2) Mouse IgG1, Kappa None $460
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ASPC551-1 Anti-FGFR4 Antibody (4C2), scFv fragment Mouse scFv His tag None $460
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ASPC551-P Anti-FGFR4 Antibody (4C2), PE Mouse IgG1, Kappa PE $1,180
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ASPC551-A Anti-FGFR4 Antibody (4C2), APC Mouse IgG1, Kappa APC $980
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ASPC551-H Anti-FGFR4 Antibody (4C2), HRP Mouse IgG1, Kappa HRP $600
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ASPC551-B Anti-FGFR4 Antibody (4C2), Biotin Mouse IgG1, Kappa Biotin $680
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Custom Antibody We can also offer conjugation antibodies (Alexa Fluor, Cy, APC, etc.) and other format antibodies (low endotoxin, Fab, scFv, etc.)

  • Anti-FGFR4 Monoclonal Antibody (4C2)
    • Product Description:
      The Anti-FGFR4 antibody is a mouse monoclonal antibody recommended for use in ELISA, western blot, flow cytometry, immunohistochemistry, immunoprecipitation and other applications. This antibody specifically targets FGFR4 and demonstrates reactivity with human.
      Applications:
      Enzyme-Linked Immunosorbent Assay, Western Blot, Flow Cytometry, Immunohistochemistry, Immunoprecipitation
      Target:
      FGFR4
      Target Species:
      Human
      Specificity:
      This antibody reacts with human FGFR4.
      Immunogen:
      Human FGFR4 protein
      Clonality:
      Monoclonal
      Clone ID:
      4C2
      Purification:
      The antibody was purified by affinity chromatography.
      Purity:
      >95% as determined by SDS-PAGE
      Aggregation:
      <5% as determined by SEC
      Form:
      Liquid
      Endotoxin:
      Please contact us for more information.
      Formulation:
      Contact us for custom product formulation.
      Preservative:
      BSA and Azide free.
      Stabilizer:
      None
      Shipping:
      Shipped at 4°C.
      Storage:
      This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
  • Anti-FGFR4 Monoclonal Antibody (4C2) Applications
    • Note:
      Optimal dilutions/concentrations should be determined by the end user.
Gene Symbol
FGFR4
Protein Name
Fibroblast growth factor receptor 4
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein would consist of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. The genomic organization of this gene, compared to members 1-3, encompasses 18 exons rather than 19 or 20. Although alternative splicing has been observed, there is no evidence that the C-terminal half of the IgIII domain of this protein varies between three alternate forms, as indicated for members 1-3. This particular family member preferentially binds acidic fibroblast growth factor and, although its specific function is unknown, it is overexpressed in gynecological tumor samples, suggesting a role in breast and ovarian tumorigenesis.
Alternative Names
Fibroblast Growth Factor Receptor 4; EC 2.7.10.1; JTK2; TKF; Tyrosine Kinase Related To Fibroblast Growth Factor Receptor; Hydroxyaryl-Protein Kinase; Protein-Tyrosine Kinase; Tyrosylprotein Kinase; CD334 Antigen; EC 2.7.10; FGFR-4; CD334
Gene ID
UniProt
Molecule Mass
Adhesion Molecules, CD Molecules
Tissue Specificity
Expressed in gastrointestinal epithelial cells, pancreas, and gastric and pancreatic cancer cell lines.
Cell Line Specificity
Cancer enhanced
Function
Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays a role in the regulation of cell proliferation, differentiation and migration, and in regulation of lipid metabolism, bile acid biosynthesis, glucose uptake, vitamin D metabolism and phosphate homeostasis. Required for normal down-regulation of the expression of CYP7A1, the rate-limiting enzyme in bile acid synthesis, in response to FGF19. Phosphorylates PLCG1 and FRS2. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes SRC-dependent phosphorylation of the matrix protease MMP14 and its lysosomal degradation. FGFR4 signaling is down-regulated by receptor internalization and degradation; MMP14 promotes internalization and degradation of FGFR4. Mutations that lead to constitutive kinase activation or impair normal FGFR4 inactivation lead to aberrant signaling.
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