Anti-FGFR2 Monoclonal Antibody (16G4)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC695	Anti-FGFR2 Antibody (16G4)	Human IgG1, Lambda	None	$460	In stock	Add
ASPC695-P	Anti-FGFR2 Antibody (16G4), PE	Human IgG1, Lambda	PE	$1,180	2-3 weeks	Add
ASPC695-A	Anti-FGFR2 Antibody (16G4), APC	Human IgG1, Lambda	APC	$980	2-3 weeks	Add
ASPC695-H	Anti-FGFR2 Antibody (16G4), HRP	Human IgG1, Lambda	HRP	$600	2-3 weeks	Add
ASPC695-B	Anti-FGFR2 Antibody (16G4), Biotin	Human IgG1, Lambda	Biotin	$680	2-3 weeks	Add

Anti-FGFR2 Monoclonal Antibody (16G4)
- Product Description:
  
  The Anti-FGFR2 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry and other applications. This antibody specifically targets FGFR2 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Western Blot
  
  Target:
  
  FGFR2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human FGFR2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  16G4
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-FGFR2 Monoclonal Antibody (16G4) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

FGFR2

Protein Name

Fibroblast growth factor receptor 2

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor receptor family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member is a high-affinity receptor for acidic, basic and/or keratinocyte growth factor, depending on the isoform. Mutations in this gene are associated with Crouzon syndrome, Pfeiffer syndrome, Craniosynostosis, Apert syndrome, Jackson-Weiss syndrome, Beare-Stevenson cutis gyrata syndrome, Saethre-Chotzen syndrome, and syndromic craniosynostosis.

Alternative Names

Fibroblast Growth Factor Receptor 2; Keratinocyte Growth Factor Receptor; Bacteria-Expressed Kinase; EC 2.7.10.1; K-SAM; KGFR; BEK; Protein Tyrosine Kinase, Receptor Like 14; BEK Fibroblast Growth Factor Receptor; Craniofacial Dysostosis 1; Jackson-Weiss Syndrome; Pfeiffer Syndrome; Crouzon Syndrome; CD332 Antigen

Gene ID

2263

UniProt

P21802

Related Disease

Crouzon syndrome (CS)

Cell Line Specificity

Cancer enhanced

Function

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of cell proliferation, differentiation, migration and apoptosis, and in the regulation of embryonic development. Required for normal embryonic patterning, trophoblast function, limb bud development, lung morphogenesis, osteogenesis and skin development. Plays an essential role in the regulation of osteoblast differentiation, proliferation and apoptosis, and is required for normal skeleton development. Promotes cell proliferation in keratinocytes and immature osteoblasts, but promotes apoptosis in differentiated osteoblasts. Phosphorylates PLCG1, FRS2 and PAK4. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. FGFR2 signaling is down-regulated by ubiquitination, internalization and degradation. Mutations that lead to constitutive kinase activation or impair normal FGFR2 maturation, internalization and degradation lead to aberrant signaling. Over-expressed FGFR2 promotes activation of STAT1.

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