Anti-FGFR1 Monoclonal Antibody (14A10)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC200	Anti-FGFR1 Antibody (14A10)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC200-P	Anti-FGFR1 Antibody (14A10), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC200-A	Anti-FGFR1 Antibody (14A10), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC200-H	Anti-FGFR1 Antibody (14A10), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC200-B	Anti-FGFR1 Antibody (14A10), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-FGFR1 Monoclonal Antibody (14A10)
- Product Description:
  
  The Anti-FGFR1 antibody is a human monoclonal antibody recommended for use in western blot, immunohistochemistry and other applications. This antibody specifically targets FGFR1 and demonstrates reactivity with human.
  
  Applications:
  
  Western Blot, Immunohistochemistry
  
  Target:
  
  FGFR1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human FGFR1.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  14A10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-FGFR1 Monoclonal Antibody (14A10) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

FGFR1

Protein Name

Fibroblast growth factor receptor 1

Introduction

The protein encoded by this gene is a member of the fibroblast growth factor receptor (FGFR) family, where amino acid sequence is highly conserved between members and throughout evolution. FGFR family members differ from one another in their ligand affinities and tissue distribution. A full-length representative protein consists of an extracellular region, composed of three immunoglobulin-like domains, a single hydrophobic membrane-spanning segment and a cytoplasmic tyrosine kinase domain. The extracellular portion of the protein interacts with fibroblast growth factors, setting in motion a cascade of downstream signals, ultimately influencing mitogenesis and differentiation. This particular family member binds both acidic and basic fibroblast growth factors and is involved in limb induction. Mutations in this gene have been associated with Pfeiffer syndrome, Jackson-Weiss syndrome, Antley-Bixler syndrome, osteoglophonic dysplasia, and autosomal dominant Kallmann syndrome 2. Chromosomal aberrations involving this gene are associated with stem cell myeloproliferative disorder and stem cell leukemia lymphoma syndrome.

Alternative Names

CEK; FLG; HH2; OGD; ECCL; FLT2; KAL2; BFGFR; CD331; FGFBR; FLT-2; HBGFR; N-SAM; FGFR-1; HRTFDS; bFGF-R-1

Gene ID

2260

UniProt

P11362

Related Disease

Pfeiffer syndrome (PS)

Tissue Specificity

Detected in astrocytoma, neuroblastoma and adrenal cortex cell lines. Some isoforms are detected in foreskin fibroblast cell lines, however isoform 17, isoform 18 and isoform 19 are not detected in these cells.

Cell Line Specificity

Cancer enhanced

Function

Tyrosine-protein kinase that acts as a cell-surface receptor for fibroblast growth factors and plays an essential role in the regulation of embryonic development, cell proliferation, differentiation and migration. Required for normal mesoderm patterning and correct axial organization during embryonic development, normal skeletogenesis and normal development of the gonadotropin-releasing hormone (GnRH) neuronal system. Phosphorylates PLCG1, FRS2, GAB1 and SHB. Ligand binding leads to the activation of several signaling cascades. Activation of PLCG1 leads to the production of the cellular signaling molecules diacylglycerol and inositol 1,4,5-trisphosphate. Phosphorylation of FRS2 triggers recruitment of GRB2, GAB1, PIK3R1 and SOS1, and mediates activation of RAS, MAPK1/ERK2, MAPK3/ERK1 and the MAP kinase signaling pathway, as well as of the AKT1 signaling pathway. Promotes phosphorylation of SHC1, STAT1 and PTPN11/SHP2. In the nucleus, enhances RPS6KA1 and CREB1 activity and contributes to the regulation of transcription. FGFR1 signaling is down-regulated by IL17RD/SEF, and by FGFR1 ubiquitination, internalization and degradation.

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