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Anti-FGF19 Monoclonal Antibody (16F6)
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Product Description:The Anti-FGF19 antibody is a mouse monoclonal antibody recommended for use in ELISA, immunoprecipitation, western blot, blocking and other applications. This antibody specifically targets FGF19 and demonstrates reactivity with human.Applications:Enzyme-Linked Immunosorbent Assay, Immunoprecipitation, Western Blot, BlockingTarget:FGF19Target Species:HumanSpecificity:This antibody reacts with human FGF-19 (Fibroblast growth factor 19).Immunogen:Human Fibroblast Growth Factor 19 proteinClonality:MonoclonalClone ID:16F6Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-FGF19 Monoclonal Antibody (16F6) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
FGF19
Protein Name
Fibroblast growth factor 19
Introduction
The protein encoded by this gene is a member of the fibroblast growth factor (FGF) family. FGF family members possess broad mitogenic and cell survival activities, and are involved in a variety of biological processes including embryonic development cell growth, morphogenesis, tissue repair, tumor growth and invasion. This growth factor is a high affinity, heparin dependent ligand for FGFR4. Expression of this gene was detected only in fetal but not adult brain tissue. Synergistic interaction of the chick homolog and Wnt-8c has been shown to be required for initiation of inner ear development.
Alternative Names
FGF19; fibroblast growth factor 19; FGF-19
Gene ID
UniProt
Molecule Mass
Growth Factors, Cytokines/Chemokines
Subcellular Location
Secreted.
Tissue Specificity
Expressed in fetal brain, cartilage, retina, and adult gall bladder.
Cell Line Specificity
Cancer enhanced
Function
Involved in the suppression of bile acid biosynthesis through down-regulation of CYP7A1 expression, following positive regulation of the JNK and ERK1/2 cascades. Stimulates glucose uptake in adipocytes. Activity requires the presence of KLB and FGFR4.
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