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Anti-FCGR2B Monoclonal Antibody (NOV0281)
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Product Description:The Anti-FCGR2B antibody is a human monoclonal antibody recommended for use in flow cytometry, enzyme-linked immunosorbent assay, functional assay and other applications. This antibody specifically targets FCGR2B and demonstrates reactivity with human.Applications:Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Functional AssaySource:HumanTarget:FCGR2BTarget Species:HumanSpecificity:This antibody reacts with Human FCGR2B.Immunogen:Human CD32b receptor.Clonality:MonoclonalClone ID:NOV0281Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-FCGR2B Monoclonal Antibody (NOV0281) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
FCGR2B
Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-b
Introduction
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Alternative Names
CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb
Gene ID
UniProt
Related Disease
Systemic lupus erythematosus (SLE)
Tissue Specificity
Is the most broadly distributed Fc-gamma-receptor. Expressed in monocyte, neutrophils, macrophages, basophils, eosinophils, Langerhans cells, B-cells, platelets cells and placenta (endothelial cells). Not detected in natural killer cells.
Cell Line Specificity
Cancer enhanced
Function
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
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