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Anti-FCGR2B Monoclonal Antibody (11B11)
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Product Description:The Anti-FCGR2B antibody is a human monoclonal antibody recommended for use in western blot, ELISA and other applications. This antibody specifically targets FCGR2B and demonstrates reactivity with human.Applications:Western Blot, Enzyme-Linked Immunosorbent AssayTarget:FCGR2BTarget Species:HumanSpecificity:This antibody reacts with human FCGR2B.Clonality:MonoclonalClone ID:11B11Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-FCGR2B Monoclonal Antibody (11B11) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
FCGR2B
Protein Name
Low affinity immunoglobulin gamma Fc region receptor II-b
Introduction
The protein encoded by this gene is a low affinity receptor for the Fc region of immunoglobulin gamma complexes. The encoded protein is involved in the phagocytosis of immune complexes and in the regulation of antibody production by B-cells. Variations in this gene may increase susceptibilty to systemic lupus erythematosus (SLE). Several transcript variants encoding different isoforms have been found for this gene.
Alternative Names
CD32; FCG2; CD32B; FCGR2; IGFR2; FCGR2C; FcGRIIB; FcRII-c; FcgammaRIIb
Gene ID
UniProt
Related Disease
Systemic lupus erythematosus (SLE)
Subcellular Location
Cell membrane; Single-pass type I membrane protein.
Cell Line Specificity
Cancer enhanced
Function
Receptor for the Fc region of complexed or aggregated immunoglobulins gamma. Low affinity receptor. Involved in a variety of effector and regulatory functions such as phagocytosis of immune complexes and modulation of antibody production by B-cells. Binding to this receptor results in down-modulation of previous state of cell activation triggered via antigen receptors on B-cells (BCR), T-cells (TCR) or via another Fc receptor. Isoform IIB1 fails to mediate endocytosis or phagocytosis. Isoform IIB2 does not trigger phagocytosis.
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