-
Anti-FCER1A Monoclonal Antibody (CRA2)
-
Product Description:The Anti-FCER1A antibody is a human monoclonal antibody recommended for use in western blot, immunofluorescence, immunohistochemistry, flow cytometry and other applications. This antibody specifically targets FCER1A and demonstrates reactivity with human.Applications:Western Blot, Immunofluorescence, Immunohistochemistry, Flow CytometryTarget:FCER1ATarget Species:HumanSpecificity:This antibody reacts with human FCER1A.Clonality:MonoclonalClone ID:CRA2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
-
-
Anti-FCER1A Monoclonal Antibody (CRA2) Applications
-
Note:Optimal dilutions/concentrations should be determined by the end user.
-
Gene Symbol
FCER1A
Protein Name
High affinity immunoglobulin gamma Fc receptor I
Introduction
The immunoglobulin epsilon receptor (IgE receptor) is the initiator of the allergic response. When two or more high-affinity IgE receptors are brought together by allergen-bound IgE molecules, mediators such as histamine that are responsible for allergy symptoms are released. This receptor is comprised of an alpha subunit, a beta subunit, and two gamma subunits. The protein encoded by this gene represents the alpha subunit.
Alternative Names
FCE1A; FcERI; FCERIA
Gene ID
UniProt
Molecule Mass
Fc Receptors
Subcellular Location
Cell membrane
Tissue Specificity
Expressed in eosinophils.
Cell Line Specificity
Group enriched
Function
High-affinity receptor for immunoglobulin epsilon/IgE. Mediates IgE effector functions in myeloid cells. Upon IgE binding and antigen/allergen cross-linking initiates signaling pathways that lead to myeloid cell activation and differentiation. On mast cells, basophils and eosinophils stimulates the secretion of vasoactive amines, lipid mediators and cytokines that contribute to inflammatory response, tissue remodeling and cytotoxicity against microbes. Triggers the immediate hypersensitivity response to allergens as a host defense mechanism against helminth parasites, pathogenic bacteria and venom toxicity. When dysregulated, it can elicit harmful life-threatening allergic and anaphylactic reactions.
Customer Reviews
There are no reviews for Product Name.
Submit a review and receive an Amazon gift card.
Publications
There are no publications for Product Name.
If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward
