Anti-ERBB2 Monoclonal Antibody (520C9)

Subcat	Description	Isotype	Conjugate	Price
ASPR35	Anti-ERBB2 Antibody (520C9)	Mouse IgG1, Kappa	None	$530	Add
ASPR35-A	Anti-ERBB2 Antibody (520C9), APC	Mouse IgG1, Kappa	APC	$1,030	Add
ASPR35-B	Anti-ERBB2 Antibody (520C9), Biotin	Mouse IgG1, Kappa	Biotin	$760	Add
ASPR35-H	Anti-ERBB2 Antibody (520C9), HRP	Mouse IgG1, Kappa	HRP	$680	Add
ASPR35-P	Anti-ERBB2 Antibody (520C9), PE	Mouse IgG1, Kappa	PE	$1,280	Add

Anti-ERBB2 Monoclonal Antibody (520C9)
- Product Description:
  
  The anti-ERBB2 antibody is a mouse monoclonal antibody recommended for Immunoprecipitation, Immunofluorescence, Immunohistochemistry. This antibody specifically targets ERBB2 and demonstrates reactivity with human.
  
  Applications:
  
  Immunoprecipitation, Immunofluorescence, Immunohistochemistry
  
  Target:
  
  ERBB2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human ERBB2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  520C9
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  The concentration of the antibody is 1 mg/mL, but it may vary depending on the specific lot.
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Preservative:
  
  Azide free
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ERBB2 Monoclonal Antibody (520C9) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ERBB2

Protein Name

Receptor Tyrosine-Protein Kinase Erbb-2

Introduction

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative Names

ERBB2; erb-b2 receptor tyrosine kinase 2; NEU; NGL; HER2; TKR1; CD340; HER-2; MLN 19; HER-2/neu; receptor tyrosine-protein kinase erbB-2; herstatin; p185erbB2; proto-oncogene Neu; c-erb B2/neu protein; proto-oncogene c-ErbB-2; metastatic lymph node gene 1

Gene ID

2064

UniProt

P04626

Related Disease

Glioma (GLM); Ovarian cancer (OC); Lung cancer (LNCR); Gastric cancer (GASC); Visceral neuropathy, familial, 2, autosomal recessive (VSCN2)

Subcellular Location

Cell membrane
Cell projection
Cytoplasm
Endosome
Membrane
Nucleus

Tissue Specificity

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.Curated
In the nucleus is involved in transcriptional regulation. Associates with the 5'-TCAAATTC-3' sequence in the PTGS2/COX-2 promoter and activates its transcription. Implicated in transcriptional activation of CDKN1A; the function involves STAT3 and SRC. Involved in the transcription of rRNA genes by RNA Pol I and enhances protein synthesis and cell growth.

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