Anti-ERBB2 Monoclonal Antibody (15A2)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC856	Anti-ERBB2 Antibody (15A2)	Human IgG1, Kappa		None	$460	In stock	Add
ASPC856-1	Anti-ERBB2 Antibody (15A2), Fab fragment	Human Fab	His tag	None	$460	In stock	Add
ASPC856-P	Anti-ERBB2 Antibody (15A2), PE	Human IgG1, Kappa		PE	$1,180	2-3 weeks	Add
ASPC856-A	Anti-ERBB2 Antibody (15A2), APC	Human IgG1, Kappa		APC	$980	2-3 weeks	Add
ASPC856-H	Anti-ERBB2 Antibody (15A2), HRP	Human IgG1, Kappa		HRP	$600	2-3 weeks	Add
ASPC856-B	Anti-ERBB2 Antibody (15A2), Biotin	Human IgG1, Kappa		Biotin	$680	2-3 weeks	Add

Anti-ERBB2 Monoclonal Antibody (15A2)
- Product Description:
  
  The Anti-ERBB2 antibody is a human monoclonal antibody recommended for use in ELISA, western blot and other applications. This antibody specifically targets ERBB2 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Target:
  
  ErbB2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human ErbB2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  15A2
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-ERBB2 Monoclonal Antibody (15A2) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

ERBB2

Protein Name

Receptor tyrosine-protein kinase erbB-2

Introduction

This gene encodes a member of the epidermal growth factor (EGF) receptor family of receptor tyrosine kinases. This protein has no ligand binding domain of its own and therefore cannot bind growth factors. However, it does bind tightly to other ligand-bound EGF receptor family members to form a heterodimer, stabilizing ligand binding and enhancing kinase-mediated activation of downstream signalling pathways, such as those involving mitogen-activated protein kinase and phosphatidylinositol-3 kinase. Allelic variations at amino acid positions 654 and 655 of isoform a (positions 624 and 625 of isoform b) have been reported, with the most common allele, Ile654/Ile655, shown here. Amplification and/or overexpression of this gene has been reported in numerous cancers, including breast and ovarian tumors. Alternative splicing results in several additional transcript variants, some encoding different isoforms and others that have not been fully characterized.

Alternative Names

Erb-B2 Receptor Tyrosine Kinase 2; V-Erb-B2 Avian Erythroblastic Leukemia Viral Oncogene Homolog 2; Tyrosine Kinase-Type Cell Surface Receptor HER2; Neuro/Glioblastoma Derived Oncogene Homolog; Human Epidermal Growth Factor Receptor 2; Metastatic Lymph Node Gene 19 Protein; Proto-Oncogene C-ErbB-2; Proto-Oncogene Neu; EC 2.7.10.1; P185erbB2; MLN 19; HER2; NGL; NEU

Gene ID

2064

UniProt

P04626

Molecule Mass

Adhesion Molecules, CD Molecules

Related Disease

Glioma (GLM)

Subcellular Location

Cell membrane

Tissue Specificity

Expressed in a variety of tumor tissues including primary breast tumors and tumors from small bowel, esophagus, kidney and mouth.

Cell Line Specificity

Group enriched

Function

Protein tyrosine kinase that is part of several cell surface receptor complexes, but that apparently needs a coreceptor for ligand binding. Essential component of a neuregulin-receptor complex, although neuregulins do not interact with it alone. GP30 is a potential ligand for this receptor. Regulates outgrowth and stabilization of peripheral microtubules (MTs). Upon ERBB2 activation, the MEMO1-RHOA-DIAPH1 signaling pathway elicits the phosphorylation and thus the inhibition of GSK3B at cell membrane. This prevents the phosphorylation of APC and CLASP2, allowing its association with the cell membrane. In turn, membrane-bound APC allows the localization of MACF1 to the cell membrane, which is required for microtubule capture and stabilization.

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