Anti-EPHA2 Monoclonal Antibody (1F7)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price
ASPC528	Anti-EPHA2 Antibody (1F7)	Human IgG1, Kappa		None	$460	Add
ASPC528-1	Anti-EPHA2 Antibody (1F7), scFv fragment	Human scFv	His tag	None	$460	Add
ASPC528-P	Anti-EPHA2 Antibody (1F7), PE	Human IgG1, Kappa		PE	$1,180	Add
ASPC528-A	Anti-EPHA2 Antibody (1F7), APC	Human IgG1, Kappa		APC	$980	Add
ASPC528-H	Anti-EPHA2 Antibody (1F7), HRP	Human IgG1, Kappa		HRP	$600	Add
ASPC528-B	Anti-EPHA2 Antibody (1F7), Biotin	Human IgG1, Kappa		Biotin	$680	Add

Anti-EPHA2 Monoclonal Antibody (1F7)
- Product Description:
  
  The Anti-EPHA2 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, immunofluorescence and other applications. This antibody specifically targets EPHA2 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunofluorescence
  
  Target:
  
  EPHA2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human EPHA2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1F7
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-EPHA2 Monoclonal Antibody (1F7) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

EPHA2

Protein Name

Ephrin type-A receptor 2

Introduction

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.

Alternative Names

EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase

Gene ID

1969

UniProt

P29317

Molecule Mass

Adhesion Molecules, Protein Kinases/Phosphatase

Related Disease

Cataract 6, multiple types (CTRCT6)

Subcellular Location

Cell membrane

Tissue Specificity

Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.

Cell Line Specificity

Low cancer specificity

Function

Receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Activated by the ligand ephrin-A1/EFNA1 regulates migration, integrin-mediated adhesion, proliferation and differentiation of cells. Regulates cell adhesion and differentiation through DSG1/desmoglein-1 and inhibition of the ERK1/ERK2 (MAPK3/MAPK1, respectively) signaling pathway. May also participate in UV radiation-induced apoptosis and have a ligand-independent stimulatory effect on chemotactic cell migration. During development, may function in distinctive aspects of pattern formation and subsequently in development of several fetal tissues. Involved for instance in angiogenesis, in early hindbrain development and epithelial proliferation and branching morphogenesis during mammary gland development. Engaged by the ligand ephrin-A5/EFNA5 may regulate lens fiber cells shape and interactions and be important for lens transparency development and maintenance. With ephrin-A2/EFNA2 may play a role in bone remodeling through regulation of osteoclastogenesis and osteoblastogenesis.

Customer Reviews

There are no reviews for Product Name.

Submit a review and receive an Amazon gift card.

Publications

There are no publications for Product Name.

If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward