Anti-EPHA2 Monoclonal Antibody (1C1)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC020	Anti-EPHA2 Antibody (1C1)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC020-P	Anti-EPHA2 Antibody (1C1), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC020-A	Anti-EPHA2 Antibody (1C1), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC020-H	Anti-EPHA2 Antibody (1C1), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC020-B	Anti-EPHA2 Antibody (1C1), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-EPHA2 Monoclonal Antibody (1C1)
- Product Description:
  
  The 1C1 antibody specifically binds to the ligand-binding domain of the EphA2 protein. The ligand-binding domain (LBD) at the amino terminus of the EphA2 ectodomain is a specific region within the EphA2 receptor protein that interacts with its ligands, primarily members of the ephrin-A family. EphA2, part of the larger Eph receptor family (a subgroup of receptor tyrosine kinases), is essential for cell signaling processes involved in cell adhesion, migration, and tissue organization.
  
  Applications:
  
  Agonist, Internalization, Enzyme-Linked Immunosorbent Assay, Western Blot, Flow Cytometry, Immunofluorescence
  
  Source:
  
  Human
  
  Target:
  
  EPHA2
  
  Target Species:
  
  Human
  
  Specificity:
  
  EphA2 LBD (ligand-binding domain)
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1C1
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-EPHA2 Monoclonal Antibody (1C1) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

EPHA2

Protein Name

Ephrin type-A receptor 2

Molecular Family

Adhesion Molecules, Protein Kinases/Phosphatase

Introduction

This gene belongs to the ephrin receptor subfamily of the protein-tyrosine kinase family. EPH and EPH-related receptors have been implicated in mediating developmental events, particularly in the nervous system. Receptors in the EPH subfamily typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. This gene encodes a protein that binds ephrin-A ligands. Mutations in this gene are the cause of certain genetically-related cataract disorders.

Alternative Names

EPH Receptor A2; Tyrosine-Protein Kinase Receptor ECK; EC 2.7.10.1; ECK; Epithelial Cell Receptor Protein Tyrosine Kinase; Ephrin Type-A Receptor 2; Soluble EPHA2 Variant 1; Epithelial Cell Kinase

Gene ID

1969

UniProt

P29317

Related Disease

Cataract 6, multiple types (CTRCT6)

Subcellular Location

Nuclear speckles,Golgi apparatus,Plasma membrane,Cell Junctions

Tissue Specificity

Expressed in brain and glioma tissue and glioma cell lines (at protein level). Expressed most highly in tissues that contain a high proportion of epithelial cells, e.g. skin, intestine, lung, and ovary.

Cell Type

B cells, Epithelial cells, Fibroblasts, Granulocytes, Monocytes, Plasma cells, T cells

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