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Anti-EPCAM Monoclonal Antibody (Adecatumumab)
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Product Description:The Anti-EPCAM antibody is a human monoclonal antibody recommended for use in immunohistochemistry, flow cytometry, enzyme-linked immunosorbent assay, western blot, functional assay and other applications. This antibody specifically targets EPCAM and demonstrates reactivity with human.Applications:Immunohistochemistry, Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Western Blot, Functional AssayTarget:EPCAMTarget Species:HumanSpecificity:This antibody reacts with Human EPCAM.Clonality:MonoclonalClone ID:AdecatumumabClone Synonyms:MT201Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-EPCAM Monoclonal Antibody (Adecatumumab) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
EPCAM
Protein Name
Epithelial cell adhesion molecule
Introduction
This gene encodes a carcinoma-associated antigen and is a member of a family that includes at least two type I membrane proteins. This antigen is expressed on most normal epithelial cells and gastrointestinal carcinomas and functions as a homotypic calcium-independent cell adhesion molecule. The antigen is being used as a target for immunotherapy treatment of human carcinomas. Mutations in this gene result in congenital tufting enteropathy.
Alternative Names
EPCAM; epithelial cell adhesion molecule; ESA; KSA; M4S1; MK-1; DIAR5; EGP-2; EGP40; KS1/4; MIC18; TROP1; EGP314; HNPCC8; TACSTD1
Gene ID
UniProt
Related Disease
Diarrhea 5, with tufting enteropathy, congenital (DIAR5)
Subcellular Location
Lateral cell membrane
Tissue Specificity
Highly and selectively expressed by undifferentiated rather than differentiated embryonic stem cells (ESC). Levels rapidly diminish as soon as ESC's differentiate (at protein levels). Expressed in almost all epithelial cell membranes but not on mesodermal or neural cell membranes. Found on the surface of adenocarcinoma.
Cell Line Specificity
Cancer enhanced
Function
May act as a physical homophilic interaction molecule between intestinal epithelial cells (IECs) and intraepithelial lymphocytes (IELs) at the mucosal epithelium for providing immunological barrier as a first line of defense against mucosal infection. Plays a role in embryonic stem cells proliferation and differentiation. Up-regulates the expression of FABP5, MYC and cyclins A and E.
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