Anti-EGFR Monoclonal Antibody (Matuzumab)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC030	Anti-EGFR Antibody (Matuzumab)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC030-P	Anti-EGFR Antibody (Matuzumab), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC030-A	Anti-EGFR Antibody (Matuzumab), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC030-H	Anti-EGFR Antibody (Matuzumab), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC030-B	Anti-EGFR Antibody (Matuzumab), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC030

Anti-EGFR Antibody (Matuzumab)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC030-P

Anti-EGFR Antibody (Matuzumab), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC030-A

Anti-EGFR Antibody (Matuzumab), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC030-H

Anti-EGFR Antibody (Matuzumab), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC030-B

Anti-EGFR Antibody (Matuzumab), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-EGFR Monoclonal Antibody (Matuzumab)
- Product Description:
  
  Matuzumab is a humanized antagonist antibody that targets the epidermal growth factor receptor (EGFR or HER1). Matuzumab targets an epitope within the extracellular domain of EGFR. By binding to this region, it prevents the receptor from interacting with its natural ligands (EGF and TGF-α), which are essential for receptor activation.
  
  Applications:
  
  Antagonist, Western Blot, Blocking, Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunofluorescence
  
  Target:
  
  EGFR
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody recongnizes the extracellular domain III of the human EGFR.
  
  Immunogen:
  
  A431 cells
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  Matuzumab
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-EGFR Monoclonal Antibody (Matuzumab) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

EGFR

Protein Name

Epidermal growth factor receptor

Molecular Family

CD Molecules, Growth Factors

Introduction

The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.

Alternative Names

Epidermal Growth Factor Receptor; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; ERBB1; ERBB; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian)

Gene ID

1956

UniProt

P00533

Related Disease

Lung cancer (LNCR)

Subcellular Location

Nucleoplasm,Nucleoli,Plasma membrane,Cell Junctions

Tissue Specificity

Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.

Cell Type

Leukocytes, Tregs