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Anti-EGFR Monoclonal Antibody (14C4)
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Product Description:The Anti-EGFR antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry, immunohistochemistry, neutralization and other applications. This antibody specifically targets EGFR and demonstrates reactivity with human, mouse.Applications:Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Immunohistochemistry, Neutralization, Western BlotTarget:EGFRTarget Species:HumanSpecificity:This antibody reacts with human EGFR.Clonality:MonoclonalClone ID:14C4Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-EGFR Monoclonal Antibody (14C4) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
EGFR
Protein Name
Epidermal growth factor receptor
Introduction
The protein encoded by this gene is a transmembrane glycoprotein that is a member of the protein kinase superfamily. This protein is a receptor for members of the epidermal growth factor family. EGFR is a cell surface protein that binds to epidermal growth factor. Binding of the protein to a ligand induces receptor dimerization and tyrosine autophosphorylation and leads to cell proliferation. Mutations in this gene are associated with lung cancer.
Alternative Names
Epidermal Growth Factor Receptor; Receptor Tyrosine-Protein Kinase ErbB-1; Erb-B2 Receptor Tyrosine Kinase 1; Proto-Oncogene C-ErbB-1; EC 2.7.10.1; ERBB1; ERBB; HER1; Epidermal Growth Factor Receptor (Avian Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog); Erythroblastic Leukemia Viral (V-Erb-B) Oncogene Homolog (Avian)
Gene ID
UniProt
Molecule Mass
CD Molecules, Growth Factors
Related Disease
Lung cancer (LNCR)
Subcellular Location
Cell membrane
Tissue Specificity
Ubiquitously expressed. Isoform 2 is also expressed in ovarian cancers.
Cell Line Specificity
Low cancer specificity
Function
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Plays a role in enhancing learning and memory performance (By similarity). Plays a role in mammalian pain signaling (long-lasting hypersensitivity) (By similarity).
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