Anti-EFNB2 Monoclonal Antibody (7A2)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC352	Anti-EFNB2 Antibody (7A2)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC352-P	Anti-EFNB2 Antibody (7A2), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC352-A	Anti-EFNB2 Antibody (7A2), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC352-H	Anti-EFNB2 Antibody (7A2), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC352-B	Anti-EFNB2 Antibody (7A2), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-EFNB2 Monoclonal Antibody (7A2)
- Product Description:
  
  The Anti-EFNB2 antibody is a human monoclonal antibody recommended for use in ELISA and other applications. This antibody specifically targets human EFNB2.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Target:
  
  EFNB2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Ephrin-b2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  7A2
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-EFNB2 Monoclonal Antibody (7A2) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

EFNB2

Protein Name

Ephrin-B2

Introduction

This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors.

Alternative Names

EFNB2; ephrin-B2; HTKL; EPLG5; Htk-L; LERK5; LERK-5; HTK ligand; ligand of eph-related kinase 5; eph-related receptor tyrosine kinase ligand 5

Gene ID

1948

UniProt

P52799

Subcellular Location

Cell membrane

Tissue Specificity

Lung and kidney.

Cell Line Specificity

Low cancer specificity

Function

Cell surface transmembrane ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Binds to receptor tyrosine kinase including EPHA4, EPHA3 and EPHB4. Together with EPHB4 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation from EFNB2-expressing cells. May play a role in constraining the orientation of longitudinally projecting axons.

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