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Anti-EFNA3 Monoclonal Antibody (D-11E2)
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Product Description:The Anti-EFNA3 antibody is a mouse monoclonal antibody recommended for western blot and other applications. This antibody specifically targets human EFNA3.Applications:Western BlotSource:MouseTarget:EFNA3Target Species:HumanSpecificity:This antibody reacts with human Ephrin A3 (EFNA3).Clonality:MonoclonalClone ID:D-11E2Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-EFNA3 Monoclonal Antibody (D-11E2) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Ephrin-A3
Introduction
This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNA class ephrin.
Alternative Names
EFL2; EPLG3; Ehk1-L; LERK3
Gene ID
UniProt
Subcellular Location
Cell membrane; Lipid-anchor, GPI-anchor.
Tissue Specificity
Expressed in brain, skeletal muscle, spleen, thymus, prostate, testis, ovary, small intestine, and peripheral blood leukocytes.
Cell Line Specificity
Low cancer specificity
Function
Cell surface GPI-bound ligand for Eph receptors, a family of receptor tyrosine kinases which are crucial for migration, repulsion and adhesion during neuronal, vascular and epithelial development. Binds promiscuously Eph receptors residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling (By similarity).
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