Anti-DSC3 Monoclonal Antibody (H-10H1)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C620	Anti-DSC3 Antibody (H-10H1)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C620

Anti-DSC3 Antibody (H-10H1)

Mouse IgG

None

$460

Add

Anti-DSC3 Monoclonal Antibody (H-10H1)
- Product Description:
  
  The Anti-DSC3 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human DSC3.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  DSC3
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Desmocollin 3 (DSC3).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  H-10H1
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-DSC3 Monoclonal Antibody (H-10H1) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Desmocollin-3

Introduction

The protein encoded by this gene is a calcium-dependent glycoprotein that is a member of the desmocollin subfamily of the cadherin superfamily. These desmosomal family members, along with the desmogleins, are found primarily in epithelial cells where they constitute the adhesive proteins of the desmosome cell-cell junction and are required for cell adhesion and desmosome formation. The desmosomal family members are arranged in two clusters on chromosome 18, occupying less than 650 kb combined. Mutations in this gene are a cause of hypotrichosis and recurrent skin vesicles disorder. The protein can act as an autoantigen in pemphigus diseases, and it is also considered to be a biomarker for some cancers. Alternative splicing of this gene results in multiple transcript variants.

Alternative Names

CDHF3; DSC; DSC1; DSC2; DSC4; HT-CP

Gene ID

1825

UniProt

Q14574

Related Disease

Hypotrichosis and recurrent skin vesicles (HRSV)

Subcellular Location

Cell membrane

Cell Line Specificity

Group enriched