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Anti-DLK1 Monoclonal Antibody (16F4)
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Product Description:The Anti-DLK1 antibody is a human monoclonal antibody recommended for use in western blot, immunoprecipitation, ELISA and other applications. This antibody specifically targets DLK1 and demonstrates reactivity with human.Applications:Western Blot, Immunoprecipitation, Enzyme-Linked Immunosorbent AssayTarget:DLK1Target Species:HumanSpecificity:This antibody reacts with human DLK1.Immunogen:Human DLK1 proteinClonality:MonoclonalClone ID:16F4Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for custom product formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-DLK1 Monoclonal Antibody (16F4) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
DLK1
Protein Name
Protein delta homolog 1
Introduction
This gene encodes a transmembrane protein containing six epidermal growth factor repeats. The protein is involved in the differentiation of several cell types, including adipocytes; it is also thought to be a tumor suppressor. It is one of several imprinted genes located in a region of on chr 14q32. Certain mutations in this imprinted region can cause phenotypes similar to maternal and paternal uniparental disomy of chromosome 14 (UPD14). This gene is expressed from the paternal allele. A polymorphism within this gene has been associated with child and adolescent obesity. The mode of inheritance for this polymorphism is polar overdominance; this non-Mendelian inheritance pattern was first described in sheep with the callipyge phenotype, which is characterized by muscle hypertrophy and decreased fat mass.
Alternative Names
DLK1; delta-like 1 homolog (Drosophila); DLK; FA1; ZOG; pG2; DLK-1; PREF1; Delta1; Pref-1; protein delta homolog 1; secredeltin; fetal antigen 1; preadipocyte factor 1
Gene ID
UniProt
Subcellular Location
Membrane; Single-pass type I membrane protein. Cytoplasm
Tissue Specificity
Found within the stromal cells in close contact to the vascular structure of placental villi, yolk sac, fetal liver, adrenal cortex and pancreas and in the beta cells of the islets of Langerhans in the adult pancreas. Found also in some forms of neuroendocrine lung tumor tissue.
Cell Line Specificity
Group enriched
Function
May have a role in neuroendocrine differentiation.
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