Anti-DKK2 Monoclonal Antibody (1G11)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC527	Anti-DKK2 Antibody (1G11)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC527-P	Anti-DKK2 Antibody (1G11), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC527-A	Anti-DKK2 Antibody (1G11), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC527-H	Anti-DKK2 Antibody (1G11), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC527-B	Anti-DKK2 Antibody (1G11), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC527

Anti-DKK2 Antibody (1G11)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC527-P

Anti-DKK2 Antibody (1G11), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC527-A

Anti-DKK2 Antibody (1G11), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC527-H

Anti-DKK2 Antibody (1G11), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC527-B

Anti-DKK2 Antibody (1G11), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-DKK2 Monoclonal Antibody (1G11)
- Product Description:
  
  The Anti-DKK2 antibody is a human monoclonal antibody recommended for use in ELISA, flow cytometry, neutralization and other applications. This antibody specifically targets DKK2 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Neutralization
  
  Target:
  
  DKK2
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human DKK2.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  1G11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-DKK2 Monoclonal Antibody (1G11) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

DKK2

Protein Name

Dickkopf-related protein 2

Introduction

This gene encodes a protein that is a member of the dickkopf family. The secreted protein contains two cysteine rich regions and is involved in embryonic development through its interactions with the Wnt signaling pathway. It can act as either an agonist or antagonist of Wnt/beta-catenin signaling, depending on the cellular context and the presence of the co-factor kremen 2. Activity of this protein is also modulated by binding to the Wnt co-receptor LDL-receptor related protein 6 (LRP6).

Alternative Names

DKK-2; Dickkopf-related protein 2

Gene ID

27123

UniProt

Q9UBU2

Subcellular Location

Secreted.

Tissue Specificity

Expressed in heart, brain, skeletal muscle and lung.

Cell Line Specificity

Group enriched

Function

Antagonizes canonical Wnt signaling by inhibiting LRP5/6 interaction with Wnt and by forming a ternary complex with the transmembrane protein KREMEN that promotes internalization of LRP5/6. DKKs play an important role in vertebrate development, where they locally inhibit Wnt regulated processes such as antero-posterior axial patterning, limb development, somitogenesis and eye formation. In the adult, Dkks are implicated in bone formation and bone disease, cancer and Alzheimer disease (By similarity).

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