Anti-DIABLO Monoclonal Antibody (G-11C10)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C578	Anti-DIABLO Antibody (G-11C10)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C578

Anti-DIABLO Antibody (G-11C10)

Mouse IgG

None

$460

Add

Anti-DIABLO Monoclonal Antibody (G-11C10)
- Product Description:
  
  The Anti-DIABLO antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human DIABLO.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  DIABLO
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human Diablo IAP-Binding Mitochondrial Protein (DIABLO).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  G-11C10
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-DIABLO Monoclonal Antibody (G-11C10) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

Diablo IAP-binding mitochondrial protein

Introduction

This gene encodes an inhibitor of apoptosis protein (IAP)-binding protein. The encoded mitochondrial protein enters the cytosol when cells undergo apoptosis, and allows activation of caspases by binding to inhibitor of apoptosis proteins. Overexpression of the encoded protein sensitizes tumor cells to apoptosis. A mutation in this gene is associated with young-adult onset of nonsyndromic deafness-64. Alternative splicing results in multiple transcript variants encoding different isoforms.

Alternative Names

DFNA64; SMAC

Gene ID

56616

UniProt

Q9NR28

Related Disease

Deafness, autosomal dominant, 64 (DFNA64)

Subcellular Location

Mitochondrion

Tissue Specificity

Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed.

Cell Line Specificity

Low cancer specificity

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