Anti-DHCR7 Monoclonal Antibody (H-16G11)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Size	Price	Quantity
ASZ1C576	Anti-DHCR7 Antibody (H-16G11)	Mouse IgG		None		$460		Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASZ1C576

Anti-DHCR7 Antibody (H-16G11)

Mouse IgG

None

$460

Add

Anti-DHCR7 Monoclonal Antibody (H-16G11)
- Product Description:
  
  The Anti-DHCR7 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human DHCR7.
  
  Applications:
  
  Immunohistochemistry, Immunocytochemistry, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  DHCR7
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human 7-Dehydrocholesterol Reductase (DHCR7).
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  H-16G11
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  0.02% sodium azide
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-DHCR7 Monoclonal Antibody (H-16G11) Applications
- Recommended Dilution:
  
  Western Blot: 1:500-1:5000
  Immunohistochemistry: 1:50-1:200
  Immunocytochemistry: 1:50-1:200
  
  Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Protein Name

7-dehydrocholesterol reductase

Introduction

This gene encodes an enzyme that removes the C(7-8) double bond in the B ring of sterols and catalyzes the conversion of 7-dehydrocholesterol to cholesterol. This gene is ubiquitously expressed and its transmembrane protein localizes to the endoplasmic reticulum membrane and nuclear outer membrane. Mutations in this gene cause Smith-Lemli-Opitz syndrome (SLOS); a syndrome that is metabolically characterized by reduced serum cholesterol levels and elevated serum 7-dehydrocholesterol levels and phenotypically characterized by cognitive disability, facial dysmorphism, syndactyly of second and third toes, and holoprosencephaly in severe cases to minimal physical abnormalities and near-normal intelligence in mild cases. Alternative splicing results in multiple transcript variants that encode the same protein.

Alternative Names

SLOS

Gene ID

1717

UniProt

Q9UBM7

Related Disease

Smith-Lemli-Opitz syndrome (SLOS)

Subcellular Location

Endoplasmic reticulum membrane

Tissue Specificity

Widely expressed. Most abundant in adrenal gland, liver, testis, and brain.

Cell Line Specificity

Low cancer specificity

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