Anti-DDR1 Monoclonal Antibody (10F6)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC341	Anti-DDR1 Antibody (10F6)	Mouse IgG	None	$460	In stock	Add
ASPC341-P	Anti-DDR1 Antibody (10F6), PE	Mouse IgG	PE	$1,180	2-3 weeks	Add
ASPC341-A	Anti-DDR1 Antibody (10F6), APC	Mouse IgG	APC	$980	2-3 weeks	Add
ASPC341-H	Anti-DDR1 Antibody (10F6), HRP	Mouse IgG	HRP	$600	2-3 weeks	Add
ASPC341-B	Anti-DDR1 Antibody (10F6), Biotin	Mouse IgG	Biotin	$680	2-3 weeks	Add

Anti-DDR1 Monoclonal Antibody (10F6)
- Product Description:
  
  The Anti-DDR1 antibody is a mouse monoclonal antibody recommended for use in flow cytometry and other applications. This antibody specifically targets DDR1 and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry
  
  Target:
  
  DDR1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human DDR1 (Discoidin Domain Receptor 1).
  
  Immunogen:
  
  Human DDR1 extracellular domain
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  10F6
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-DDR1 Monoclonal Antibody (10F6) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

DDR1

Protein Name

Epithelial discoidin domain-containing receptor 1

Introduction

Receptor tyrosine kinases play a key role in the communication of cells with their microenvironment. These kinases are involved in the regulation of cell growth, differentiation and metabolism. The protein encoded by this gene belongs to a subfamily of tyrosine kinase receptors with homology to Dictyostelium discoideum protein discoidin I in their extracellular domain, and that are activated by various types of collagen. Expression of this protein is restricted to epithelial cells, particularly in the kidney, lung, gastrointestinal tract, and brain. In addition, it has been shown to be significantly overexpressed in several human tumors. Alternatively spliced transcript variants encoding different isoforms have been described for this gene.

Alternative Names

DDR1; CAK; DDR; NEP; HGK2; PTK3; RTK6; TRKE; CD167; EDDR1; MCK10; NTRK4; PTK3A

Gene ID

780

UniProt

Q08345

Molecule Mass

Adhesion Molecules, CD Molecules

Cell Line Specificity

Low cancer specificity

Function

Tyrosine kinase that functions as a cell surface receptor for fibrillar collagen and regulates cell attachment to the extracellular matrix, remodeling of the extracellular matrix, cell migration, differentiation, survival and cell proliferation. Collagen binding triggers a signaling pathway that involves SRC and leads to the activation of MAP kinases. Regulates remodeling of the extracellular matrix by up-regulation of the matrix metalloproteinases MMP2, MMP7 and MMP9, and thereby facilitates cell migration and wound healing. Required for normal blastocyst implantation during pregnancy, for normal mammary gland differentiation and normal lactation. Required for normal ear morphology and normal hearing (By similarity). Promotes smooth muscle cell migration, and thereby contributes to arterial wound healing. Also plays a role in tumor cell invasion. Phosphorylates PTPN11.

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