Anti-CXCR4 Monoclonal Antibody (I-3859)

Subcat	Description	Isotype	Conjugate	Price
ASPC1025	Anti-CXCR4 Antibody (I-3859)	Mouse IgG1, Kappa	None	$460	Add
ASPC1025-A	Anti-CXCR4 Antibody (I-3859), APC	Mouse IgG1, Kappa	APC	$980	Add
ASPC1025-B	Anti-CXCR4 Antibody (I-3859), Biotin	Mouse IgG1, Kappa	Biotin	$680	Add
ASPC1025-H	Anti-CXCR4 Antibody (I-3859), HRP	Mouse IgG1, Kappa	HRP	$600	Add
ASPC1025-P	Anti-CXCR4 Antibody (I-3859), PE	Mouse IgG1, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1025

Anti-CXCR4 Antibody (I-3859)

Mouse IgG1, Kappa

None

$460

Add

ASPC1025-A

Anti-CXCR4 Antibody (I-3859), APC

Mouse IgG1, Kappa

APC

$980

Add

ASPC1025-B

Anti-CXCR4 Antibody (I-3859), Biotin

Mouse IgG1, Kappa

Biotin

$680

Add

ASPC1025-H

Anti-CXCR4 Antibody (I-3859), HRP

Mouse IgG1, Kappa

HRP

$600

Add

ASPC1025-P

Anti-CXCR4 Antibody (I-3859), PE

Mouse IgG1, Kappa

$1,180

Add

Anti-CXCR4 Monoclonal Antibody (I-3859)
- Product Description:
  
  The Anti-CXCR4 antibody is a mouse monoclonal antibody recommended for use in immunohistochemistry, flow cytometry, enzyme-linked immunosorbent assay, immunoprecipitation and other applications. This antibody specifically targets CXCR4 and demonstrates reactivity with human.
  
  Applications:
  
  Immunohistochemistry, Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Immunoprecipitation
  
  Target:
  
  CXCR4
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human CXCR4.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  I-3859
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CXCR4 Monoclonal Antibody (I-3859) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CXCR4

Protein Name

C-X-C chemokine receptor type 4

Introduction

This gene encodes a CXC chemokine receptor specific for stromal cell-derived factor-1. The protein has 7 transmembrane regions and is located on the cell surface. It acts with the CD4 protein to support HIV entry into cells and is also highly expressed in breast cancer cells. Mutations in this gene have been associated with WHIM (warts, hypogammaglobulinemia, infections, and myelokathexis) syndrome. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative Names

CD184; D2S201E; FB22; HM89; HSY3RR; LAP-3; LAP3; LCR1; LESTR; NPY3R; NPYR; NPYRL; NPYY3R; WHIM; WHIMS

Gene ID

7852

UniProt

P61073

Subcellular Location

Cell membrane

Tissue Specificity

Expressed in numerous tissues, such as peripheral blood leukocytes, spleen, thymus, spinal cord, heart, placenta, lung, liver, skeletal muscle, kidney, pancreas, cerebellum, cerebral cortex and medulla (in microglia as well as in astrocytes), brain microvascular, coronary artery and umbilical cord endothelial cells. Isoform 1 is predominant in all tissues tested.

Cell Line Specificity

Group enriched

Function

Receptor for the C-X-C chemokine CXCL12/SDF-1 that transduces a signal by increasing intracellular calcium ion levels and enhancing MAPK1/MAPK3 activation.

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