Anti-CTLA4 Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Conjugate	Price
ASPC1014	Anti-CTLA4 Antibody	Human IgG2, Kappa	None	$460	Add
ASPC1014-A	Anti-CTLA4 Antibody, APC	Human IgG2, Kappa	APC	$980	Add
ASPC1014-B	Anti-CTLA4 Antibody, Biotin	Human IgG2, Kappa	Biotin	$680	Add
ASPC1014-H	Anti-CTLA4 Antibody, HRP	Human IgG2, Kappa	HRP	$600	Add
ASPC1014-P	Anti-CTLA4 Antibody, PE	Human IgG2, Kappa	PE	$1,180	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Quantity

ASPC1014

Anti-CTLA4 Antibody

Human IgG2, Kappa

None

$460

Add

ASPC1014-A

Anti-CTLA4 Antibody, APC

Human IgG2, Kappa

APC

$980

Add

ASPC1014-B

Anti-CTLA4 Antibody, Biotin

Human IgG2, Kappa

Biotin

$680

Add

ASPC1014-H

Anti-CTLA4 Antibody, HRP

Human IgG2, Kappa

HRP

$600

Add

ASPC1014-P

Anti-CTLA4 Antibody, PE

Human IgG2, Kappa

$1,180

Add

Anti-CTLA4 Monoclonal Antibody
- Product Description:
  
  The Anti-CTLA4 antibody is a human monoclonal antibody recommended for use in western blot, surface plasmon resonance, enzyme-linked immunosorbent assay and other applications. This antibody specifically targets CTLA4 and demonstrates reactivity with human.
  
  Applications:
  
  Western Blot, Surface Plasmon Resonance, Enzyme-Linked Immunosorbent Assay
  
  Target:
  
  CTLA4
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with Human CTLA4.
  
  Clonality:
  
  Monoclonal
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CTLA4 Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CTLA4

Protein Name

Cytotoxic T-lymphocyte protein 4

Introduction

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

Gene ID

1493

UniProt

P16410

Subcellular Location

Cell membrane

Tissue Specificity

Widely expressed with highest levels in lymphoid tissues. Detected in activated T-cells where expression levels are 30- to 50-fold less than CD28, the stimulatory coreceptor, on the cell surface following activation.

Cell Line Specificity

Cancer enhanced

Function

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

Customer Reviews

There are no reviews for Product Name.

Submit a review and receive an Amazon gift card.

Publications

There are no publications for Product Name.

If you couldn't find the specific publication, you can:
Submit a Citation Get a Publication Reward