Anti-CTLA4 Monoclonal Antibody (10A8)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC197	Anti-CTLA4 Antibody (10A8)	Mouse IgG1, Lambda	None	$460	In stock	Add
ASPC197-P	Anti-CTLA4 Antibody (10A8), PE	Mouse IgG1, Lambda	PE	$1,180	2-3 weeks	Add
ASPC197-A	Anti-CTLA4 Antibody (10A8), APC	Mouse IgG1, Lambda	APC	$980	2-3 weeks	Add
ASPC197-H	Anti-CTLA4 Antibody (10A8), HRP	Mouse IgG1, Lambda	HRP	$600	2-3 weeks	Add
ASPC197-B	Anti-CTLA4 Antibody (10A8), Biotin	Mouse IgG1, Lambda	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC197

Anti-CTLA4 Antibody (10A8)

Mouse IgG1, Lambda

None

$460

In stock

Add

ASPC197-P

Anti-CTLA4 Antibody (10A8), PE

Mouse IgG1, Lambda

$1,180

2-3 weeks

Add

ASPC197-A

Anti-CTLA4 Antibody (10A8), APC

Mouse IgG1, Lambda

APC

$980

2-3 weeks

Add

ASPC197-H

Anti-CTLA4 Antibody (10A8), HRP

Mouse IgG1, Lambda

HRP

$600

2-3 weeks

Add

ASPC197-B

Anti-CTLA4 Antibody (10A8), Biotin

Mouse IgG1, Lambda

Biotin

$680

2-3 weeks

Add

Anti-CTLA4 Monoclonal Antibody (10A8)
- Product Description:
  
  The Anti-CTLA4 antibody is a mouse monoclonal antibody recommended for use in ELISA, flow cytometry, western blot, functional assay and other applications. This antibody specifically targets CTLA4 and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Flow Cytometry, Western Blot, Functional Assay
  
  Target:
  
  CTLA4
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CTLA4.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  10A8
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CTLA4 Monoclonal Antibody (10A8) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CTLA4

Protein Name

Cytotoxic T-lymphocyte protein 4

Introduction

This gene is a member of the immunoglobulin superfamily and encodes a protein which transmits an inhibitory signal to T cells. The protein contains a V domain, a transmembrane domain, and a cytoplasmic tail. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. The membrane-bound isoform functions as a homodimer interconnected by a disulfide bond, while the soluble isoform functions as a monomer. Mutations in this gene have been associated with insulin-dependent diabetes mellitus, Graves disease, Hashimoto thyroiditis, celiac disease, systemic lupus erythematosus, thyroid-associated orbitopathy, and other autoimmune diseases.

Alternative Names

CTLA4; cytotoxic T-lymphocyte-associated protein 4; CD; GSE; GRD4; ALPS5; CD152; CTLA-4; IDDM12; CELIAC3

Gene ID

1493

UniProt

P16410

Molecule Mass

CD Molecules, Immune Checkpoint Receptors

Related Disease

Systemic lupus erythematosus (SLE)

Subcellular Location

Cell membrane

Cell Line Specificity

Cancer enhanced

Function

Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.

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