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Anti-CSPG4 Monoclonal Antibody (G-4B1)
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Product Description:The Anti-CSPG4 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human CSPG4.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:CSPG4Target Species:HumanSpecificity:This antibody reacts with human Chondroitin Sulfate Proteoglycan 4 (CSPG4).Immunogen:Recombinant CSPG4 proteinClonality:MonoclonalClone ID:G-4B1Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CSPG4 Monoclonal Antibody (G-4B1) Applications
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Recommended Dilution:Western Blot: 0.5-2 µg/mL
Immunohistochemistry: 5-20 µg/mL
Immunocytochemistry: 5-20 µg/mLNote:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Chondroitin sulfate proteoglycan 4
Introduction
CSPG4P1Y (Chondroitin Sulfate Proteoglycan 4 Pseudogene 1, Y-Linked) is a Pseudogene.
Alternative Names
HMW-MAA; MCSP; MCSPG; MEL-CSPG; MSK16; NG2
Gene ID
UniProt
Subcellular Location
Cell membrane
Cell Line Specificity
Cancer enhanced
Function
Proteoglycan playing a role in cell proliferation and migration which stimulates endothelial cells motility during microvascular morphogenesis. May also inhibit neurite outgrowth and growth cone collapse during axon regeneration. Cell surface receptor for collagen alpha 2(VI) which may confer cells ability to migrate on that substrate. Binds through its extracellular N-terminus growth factors, extracellular matrix proteases modulating their activity. May regulate MPP16-dependent degradation and invasion of type I collagen participating in melanoma cells invasion properties. May modulate the plasminogen system by enhancing plasminogen activation and inhibiting angiostatin. Also functions as a signal transducing protein by binding through its cytoplasmic C-terminus scaffolding and signaling proteins. May promote retraction fiber formation and cell polarization through Rho GTPase activation. May stimulate alpha-4, beta-1 integrin-mediated adhesion and spreading by recruiting and activating a signaling cascade through CDC42, ACK1 and BCAR1. May activate FAK and ERK1/ERK2 signaling cascades.
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