Anti-CRP Monoclonal Antibody (P24)

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC108	Anti-CRP Antibody (P24)	Mouse IgG1, Kappa		None	$460	4-6 weeks	Add
ASPC108-1	Anti-CRP Antibody (P24), Fab fragment	Mouse Fab	His tag	None	$460	In stock	Add
ASPC108-P	Anti-CRP Antibody (P24), PE	Mouse IgG1, Kappa		PE	$1,180	2-3 weeks	Add
ASPC108-A	Anti-CRP Antibody (P24), APC	Mouse IgG1, Kappa		APC	$980	2-3 weeks	Add
ASPC108-H	Anti-CRP Antibody (P24), HRP	Mouse IgG1, Kappa		HRP	$600	2-3 weeks	Add
ASPC108-B	Anti-CRP Antibody (P24), Biotin	Mouse IgG1, Kappa		Biotin	$680	2-3 weeks	Add

Anti-CRP Monoclonal Antibody (P24)
- Product Description:
  
  P24 is a monoclonal antibody that specifically binds to human C-reactive protein (CRP), a critical component of the immune system's acute phase response. CRP is a pentameric protein found in blood plasma, predominantly produced by the liver, and its levels rise significantly in response to inflammation, tissue damage, or bacterial infection.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Western Blot
  
  Source:
  
  Mouse
  
  Target:
  
  CRP
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human C reactive protein
  
  Immunogen:
  
  Human C-Reactive Protein (CRP)
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  P24
  
  Isotype:
  
  Mouse IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CRP Monoclonal Antibody (P24) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CRP

Protein Name

C-reactive protein

Introduction

The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.

Alternative Names

C-Reactive Protein; C-Reactive Protein, Pentraxin-Related; Pentraxin 1; PTX1

Gene ID

1401

UniProt

P02741

Subcellular Location

Nucleoplasm,Vesicles,Intermediate filaments

Tissue Specificity

Found in plasma.

Function

Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.

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