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Anti-CRP Monoclonal Antibody (P03)
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Product Description:The P03 antibody is a monoclonal antibody that specifically reacts with human C-reactive protein (CRP), a key player in the body's immune response, particularly during acute phases of inflammation. CRP is a pentameric protein, meaning it consists of five identical subunits, and is predominantly produced in the liver.Applications:Enzyme-Linked Immunosorbent Assay, Western BlotSource:MouseTarget:CRPTarget Species:HumanSpecificity:Human C reactive proteinImmunogen:Human C-Reactive Protein (CRP)Clonality:MonoclonalClone ID:P03Isotype:Mouse IgG1, KappaPurification:The antibody was purified by Protein A.Purity:>95% as determined by SDS-PAGEAggregation:<5% as determined by SECConcentration:1 mg/mLForm:LiquidEndotoxin:Please contact us for more information.Formulation:Contact us for customized product form or formulation.Preservative:BSA and Azide free.Stabilizer:NoneShipping:Shipped at 4°C.Storage:This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CRP Monoclonal Antibody (P03) Applications
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Note:Optimal dilutions/concentrations should be determined by the end user.
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Gene Symbol
CRP
Protein Name
C-reactive protein
Introduction
The protein encoded by this gene belongs to the pentraxin family which also includes serum amyloid P component protein and pentraxin 3. Pentraxins are involved in complement activation and amplification via communication with complement initiation pattern recognition molecules, but also complement regulation via recruitment of complement regulators. The encoded protein has a calcium dependent ligand binding domain with a distinctive flattened beta-jellyroll structure. It exists in two forms as either a pentamer in circulation or as a nonsoluble monomer in tissues. It is involved in several host defense related functions based on its ability to recognize foreign pathogens and damaged cells of the host and to initiate their elimination by interacting with humoral and cellular effector systems in the blood. Consequently, the level of this protein in plasma increases greatly during acute phase response to tissue injury, infection, or other inflammatory stimuli.
Alternative Names
C-Reactive Protein; C-Reactive Protein, Pentraxin-Related; Pentraxin 1; PTX1
Gene ID
UniProt
Subcellular Location
Nucleoplasm,Vesicles,Intermediate filaments
Tissue Specificity
Found in plasma.
Function
Displays several functions associated with host defense: it promotes agglutination, bacterial capsular swelling, phagocytosis and complement fixation through its calcium-dependent binding to phosphorylcholine. Can interact with DNA and histones and may scavenge nuclear material released from damaged circulating cells.
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