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Anti-COL4A1 Monoclonal Antibody (A-12E10)
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Product Description:The Anti-COL4A1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human COL4A1.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:COL4A1Target Species:HumanSpecificity:This antibody reacts with human Collagen Type IV Alpha 1 Chain (COL4A1).Immunogen:Recombinant COL4a1 proteinClonality:MonoclonalClone ID:A-12E10Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.05% Proclin 300Shipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-COL4A1 Monoclonal Antibody (A-12E10) Applications
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Recommended Dilution:Western Blot: 0.01-2 µg/mL
Immunohistochemistry: 5-20 µg/mL
Immunocytochemistry: 5-20 µg/mLNote:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Collagen alpha-1(IV) chain
Introduction
This gene encodes a type IV collagen alpha protein. Type IV collagen proteins are integral components of basement membranes. This gene shares a bidirectional promoter with a paralogous gene on the opposite strand. The protein consists of an amino-terminal 7S domain, a triple-helix forming collagenous domain, and a carboxy-terminal non-collagenous domain. It functions as part of a heterotrimer and interacts with other extracellular matrix components such as perlecans, proteoglycans, and laminins. In addition, proteolytic cleavage of the non-collagenous carboxy-terminal domain results in a biologically active fragment known as arresten, which has anti-angiogenic and tumor suppressor properties. Mutations in this gene cause porencephaly, cerebrovascular disease, and renal and muscular defects. Alternative splicing results in multiple transcript variants.
Alternative Names
BSVD; RATOR
Gene ID
UniProt
Related Disease
Hereditary angiopathy with nephropathy aneurysms and muscle cramps (HANAC)
Subcellular Location
Secreted, extracellular space, extracellular matrix, basement membrane
Tissue Specificity
Highly expressed in placenta.
Cell Line Specificity
Cancer enhanced
Function
Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.
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