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Anti-CNTN1 Monoclonal Antibody (B-8G12)
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Product Description:The Anti-CNTN1 antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human CNTN1.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:CNTN1Target Species:HumanSpecificity:This antibody reacts with human Contactin 1 (CNTN1).Clonality:MonoclonalClone ID:B-8G12Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CNTN1 Monoclonal Antibody (B-8G12) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:200
Immunocytochemistry: 1:50-1:200Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Contactin-1
Introduction
The protein encoded by this gene is a member of the immunoglobulin superfamily. It is a glycosylphosphatidylinositol (GPI)-anchored neuronal membrane protein that functions as a cell adhesion molecule. It may play a role in the formation of axon connections in the developing nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Alternative Names
F3; GP135; MYPCN
Gene ID
UniProt
Related Disease
Congenital myopathy 12 (CMYO12)
Tissue Specificity
Strongly expressed in brain and in neuroblastoma and retinoblastoma cell lines. Lower levels of expression in lung, pancreas, kidney and skeletal muscle.
Cell Line Specificity
Cancer enriched
Function
Contactins mediate cell surface interactions during nervous system development. Involved in the formation of paranodal axo-glial junctions in myelinated peripheral nerves and in the signaling between axons and myelinating glial cells via its association with CNTNAP1. Participates in oligodendrocytes generation by acting as a ligand of NOTCH1. Its association with NOTCH1 promotes NOTCH1 activation through the released notch intracellular domain (NICD) and subsequent translocation to the nucleus. Interaction with TNR induces a repulsion of neurons and an inhibition of neurite outgrowth (By similarity).
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