Anti-CMV gH Monoclonal Antibody (MSL-109)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC008	Anti-CMV gH Antibody (MSL-109)	Human IgG1, Kappa	None	$460	In stock	Add
ASPC008-P	Anti-CMV gH Antibody (MSL-109), PE	Human IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC008-A	Anti-CMV gH Antibody (MSL-109), APC	Human IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC008-H	Anti-CMV gH Antibody (MSL-109), HRP	Human IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC008-B	Anti-CMV gH Antibody (MSL-109), Biotin	Human IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Subcat

Description

Isotype

Antibody Modification

Conjugate

Size

Price

Availability

Quantity

ASPC008

Anti-CMV gH Antibody (MSL-109)

Human IgG1, Kappa

None

$460

In stock

Add

ASPC008-P

Anti-CMV gH Antibody (MSL-109), PE

Human IgG1, Kappa

$1,180

2-3 weeks

Add

ASPC008-A

Anti-CMV gH Antibody (MSL-109), APC

Human IgG1, Kappa

APC

$980

2-3 weeks

Add

ASPC008-H

Anti-CMV gH Antibody (MSL-109), HRP

Human IgG1, Kappa

HRP

$600

2-3 weeks

Add

ASPC008-B

Anti-CMV gH Antibody (MSL-109), Biotin

Human IgG1, Kappa

Biotin

$680

2-3 weeks

Add

Anti-CMV gH Monoclonal Antibody (MSL-109)
- Product Description:
  
  MSL-109 is a human monoclonal antibody that specifically targets the CMV. CMV is a common virus that can cause severe disease in immunocompromised individuals, such as transplant recipients and people with HIV. The specific epitope for MSL-109 on CMV glycoprotein H (gH) was identified as an amino acid sequence on the glycoprotein. MSL-109 binds to this conformational epitope on the gH protein, blocking a critical interaction required for viral entry into host cells.
  
  Applications:
  
  Neutralization
  
  Source:
  
  Human
  
  Target:
  
  CMV gH
  
  Target Species:
  
  Human Cytomegalovirus
  
  Strains/Serotype:
  
  Strain AD169
  
  Specificity:
  
  Human cytomegalovirus
  
  Immunogen:
  
  Cytomegalovirus antigen prepared from MRC-5 cells infected with CMV Towne strain.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  MSL-109
  
  Clone Synonyms:
  
  Sevirumab
  
  Isotype:
  
  Human IgG1, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CMV gH Monoclonal Antibody (MSL-109) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

Protein Name

Envelope glycoprotein H

Introduction

The heterodimer glycoprotein H-glycoprotein L is required for the fusion of viral and plasma membranes leading to virus entry into the host cell. Following initial binding to host receptor, membrane fusion is mediated by the fusion machinery composed of gB and the heterodimer gH/gL. May also be involved in the fusion between the virion envelope and the outer nuclear membrane during virion morphogenesis (By similarity).
In human cytomegalovirus, forms two distincts complexes to mediate viral entry, a trimer and a pentamer at the surface of the virion envelope. The gH-gL-gO trimer is required for infection in fibroblasts by interacting with host PDGFRA, and in glioblastoma cells by interacting with host EPHA2. The gH-gL-UL128-UL130-UL131A pentamer is essential for viral entry in epithelial, endothelial and myeloid cells via interaction with host NRP2 (By similarity).

Alternative Names

gH; Envelope glycoprotein H; Human cytomegalovirus (strain AD169); HHV-5

UniProt

P12824

Cell Type

B cells, NK cells, Plasma cells, T cells, Thymocytes, Tregs

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