Anti-CLDN1 Monoclonal Antibody (13B3)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC810	Anti-CLDN1 Antibody (13B3)	Mouse IgG2b, Kappa	None	$460	In stock	Add
ASPC810-P	Anti-CLDN1 Antibody (13B3), PE	Mouse IgG2b, Kappa	PE	$1,180	2-3 weeks	Add
ASPC810-A	Anti-CLDN1 Antibody (13B3), APC	Mouse IgG2b, Kappa	APC	$980	2-3 weeks	Add
ASPC810-H	Anti-CLDN1 Antibody (13B3), HRP	Mouse IgG2b, Kappa	HRP	$600	2-3 weeks	Add
ASPC810-B	Anti-CLDN1 Antibody (13B3), Biotin	Mouse IgG2b, Kappa	Biotin	$680	2-3 weeks	Add

Anti-CLDN1 Monoclonal Antibody (13B3)
- Product Description:
  
  The Anti-CLDN1 antibody is a mouse monoclonal antibody recommended for use in flow cytometry, ELISA, Immunoblotting, inhibition, immunofluorescence and other applications. This antibody specifically targets CLDN1 and demonstrates reactivity with human.
  
  Applications:
  
  Flow Cytometry, Enzyme-Linked Immunosorbent Assay, Immunoblotting, Inhibition, Immunofluorescence
  
  Target:
  
  CLDN1
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CLDN1.
  
  Immunogen:
  
  Human Claudin 1 protein
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  13B3
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CLDN1 Monoclonal Antibody (13B3) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CLDN1

Protein Name

Claudin domain-containing protein 1

Introduction

Tight junctions represent one mode of cell-to-cell adhesion in epithelial or endothelial cell sheets, forming continuous seals around cells and serving as a physical barrier to prevent solutes and water from passing freely through the paracellular space. These junctions are comprised of sets of continuous networking strands in the outwardly facing cytoplasmic leaflet, with complementary grooves in the inwardly facing extracytoplasmic leaflet. The protein encoded by this gene, a member of the claudin family, is an integral membrane protein and a component of tight junction strands. Loss of function mutations result in neonatal ichthyosis-sclerosing cholangitis syndrome.

Alternative Names

CLDN1; claudin 1; CLD1; SEMP1; ILVASC; claudin-1; senescence-associated epithelial membrane protein 1

Gene ID

9076

UniProt

O95832

Related Disease

Ichthyosis-sclerosing cholangitis neonatal syndrome (NISCH)

Subcellular Location

Cell junction, tight junction

Tissue Specificity

Strongly expressed in liver and kidney. Expressed in heart, brain, spleen, lung and testis.

Cell Line Specificity

Low cancer specificity

Function

Claudins function as major constituents of the tight junction complexes that regulate the permeability of epithelia. While some claudin family members play essential roles in the formation of impermeable barriers, others mediate the permeability to ions and small molecules. Often, several claudin family members are coexpressed and interact with each other, and this determines the overall permeability. CLDN1 is required to prevent the paracellular diffusion of small molecules through tight junctions in the epidermis and is required for the normal barrier function of the skin. Required for normal water homeostasis and to prevent excessive water loss through the skin, probably via an indirect effect on the expression levels of other proteins, since CLDN1 itself seems to be dispensable for water barrier formation in keratinocyte tight junctions.

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