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Anti-CFB Monoclonal Antibody (D-15D3)
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Product Description:The Anti-CFB antibody is a mouse monoclonal antibody recommended for immunohistochemistry, immunocytochemistry, western blot, immunoprecipitation and other applications. This antibody specifically targets human CFB.Applications:Immunohistochemistry, Immunocytochemistry, Western Blot, ImmunoprecipitationSource:MouseTarget:CFBTarget Species:HumanSpecificity:This antibody reacts with human Complement Factor B (CFB).Clonality:MonoclonalClone ID:D-15D3Purification:The antibody was purified by affinity chromatography.Purity:>95% as determined by SDS-PAGEConcentration:1 mg/mLForm:LiquidFormulation:Contact us for custom product formulation.Preservative:0.02% sodium azideShipping:Shipped at 4°C.Storage:This antibody can be stored at 2°C-8°C for one month. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
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Anti-CFB Monoclonal Antibody (D-15D3) Applications
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Recommended Dilution:Western Blot: 1:500-1:5000
Immunohistochemistry: 1:50-1:200
Immunocytochemistry: 1:50-1:200Note:Optimal dilutions/concentrations should be determined by the end user.
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Protein Name
Complement factor B
Introduction
This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.
Alternative Names
AHUS4; ARMD14; BF; BFD; CFABD; FB; FBI12; GBG; H2-Bf; PBF2; CFB
Gene ID
UniProt
Related Disease
Macular degeneration, age-related, 14 (ARMD14)
Subcellular Location
Secreted
Cell Line Specificity
Cancer enriched
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