Anti-CFB Monoclonal Antibody (2A2)

Subcat	Description	Isotype	Conjugate	Price	Availability
ASPC595	Anti-CFB Antibody (2A2)	Mouse IgG1, Kappa	None	$460	In stock	Add
ASPC595-P	Anti-CFB Antibody (2A2), PE	Mouse IgG1, Kappa	PE	$1,180	2-3 weeks	Add
ASPC595-A	Anti-CFB Antibody (2A2), APC	Mouse IgG1, Kappa	APC	$980	2-3 weeks	Add
ASPC595-H	Anti-CFB Antibody (2A2), HRP	Mouse IgG1, Kappa	HRP	$600	2-3 weeks	Add
ASPC595-B	Anti-CFB Antibody (2A2), Biotin	Mouse IgG1, Kappa	Biotin	$680	2-3 weeks	Add

Anti-CFB Monoclonal Antibody (2A2)
- Product Description:
  
  The Anti-CFB antibody is a mouse monoclonal antibody recommended for use in ELISA, inhibition, flow cytometry and other applications. This antibody specifically targets CFB and demonstrates reactivity with human.
  
  Applications:
  
  Enzyme-Linked Immunosorbent Assay, Inhibition, Flow Cytometry
  
  Target:
  
  CFB
  
  Target Species:
  
  Human
  
  Specificity:
  
  This antibody reacts with human CFB.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  2A2
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CFB Monoclonal Antibody (2A2) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CFB

Protein Name

Complement factor B

Introduction

This gene encodes complement factor B, a component of the alternative pathway of complement activation. Factor B circulates in the blood as a single chain polypeptide. Upon activation of the alternative pathway, it is cleaved by complement factor D yielding the noncatalytic chain Ba and the catalytic subunit Bb. The active subunit Bb is a serine protease which associates with C3b to form the alternative pathway C3 convertase. Bb is involved in the proliferation of preactivated B lymphocytes, while Ba inhibits their proliferation. This gene localizes to the major histocompatibility complex (MHC) class III region on chromosome 6. This cluster includes several genes involved in regulation of the immune reaction. Polymorphisms in this gene are associated with a reduced risk of age-related macular degeneration. The polyadenylation site of this gene is 421 bp from the 5' end of the gene for complement component 2.

Alternative Names

Complement Factor B; B-Factor, Properdin; Properdin Factor B; C3/C5 Convertase; EC 3.4.21.47; PBF2; BFD; GBG; BF

Gene ID

629

UniProt

P00751

Related Disease

Macular degeneration, age-related, 14 (ARMD14)

Subcellular Location

Secreted.

Cell Line Specificity

Cancer enriched

Function

Factor B which is part of the alternate pathway of the complement system is cleaved by factor D into 2 fragments: Ba and Bb. Bb, a serine protease, then combines with complement factor 3b to generate the C3 or C5 convertase. It has also been implicated in proliferation and differentiation of preactivated B-lymphocytes, rapid spreading of peripheral blood monocytes, stimulation of lymphocyte blastogenesis and lysis of erythrocytes. Ba inhibits the proliferation of preactivated B-lymphocytes.

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