Anti-CD8A Monoclonal Antibody (YTS 105.18)

Subcat	Description	Isotype	Conjugate	Price
ASPC978	Anti-CD8A Antibody (YTS 105.18)	Rat IgG2a, Kappa	None	$460	Add
ASPC978-A	Anti-CD8A Antibody (YTS 105.18), APC	Rat IgG2a, Kappa	APC	$980	Add
ASPC978-B	Anti-CD8A Antibody (YTS 105.18), Biotin	Rat IgG2a, Kappa	Biotin	$680	Add
ASPC978-H	Anti-CD8A Antibody (YTS 105.18), HRP	Rat IgG2a, Kappa	HRP	$600	Add
ASPC978-P	Anti-CD8A Antibody (YTS 105.18), PE	Rat IgG2a, Kappa	PE	$1,180	Add

Anti-CD8A Monoclonal Antibody (YTS 105.18)
- Product Description:
  
  The Anti-CD8A antibody is a rat monoclonal antibody recommended for use in immunohistochemistry-frozen, immunofluorescence, flow cytometry, blocking and other applications. This antibody specifically targets CD8A and demonstrates reactivity with mouse.
  
  Applications:
  
  Immunohistochemistry-Frozen, Immunofluorescence, Flow Cytometry, Blocking
  
  Target:
  
  CD8A
  
  Specificity:
  
  This antibody reacts with CD8A.
  
  Clonality:
  
  Monoclonal
  
  Clone ID:
  
  YTS 105.18
  
  Purification:
  
  The antibody was purified by affinity chromatography.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for custom product formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be stored at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD8A Monoclonal Antibody (YTS 105.18) Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

Cd8a

Protein Name

T-cell surface glycoprotein CD8 alpha chain

Introduction

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.

Alternative Names

CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; T-Cell Surface Glycoprotein CD8 Alpha Chain; CD8 Antigen, Alpha Polypeptide (P32); MAL

Gene ID

12525

UniProt

P01731

Subcellular Location

Cell membrane

Function

Integral membrane glycoprotein that plays an essential role in the immune response and serves multiple functions in responses against both external and internal offenses. In T-cells, functions primarily as a coreceptor for MHC class I molecule:peptide complex. The antigens presented by class I peptides are derived from cytosolic proteins while class II derived from extracellular proteins. Interacts simultaneously with the T-cell receptor (TCR) and the MHC class I proteins presented by antigen presenting cells (APCs). In turn, recruits the Src kinase LCK to the vicinity of the TCR-CD3 complex. LCK then initiates different intracellular signaling pathways by phosphorylating various substrates ultimately leading to lymphokine production, motility, adhesion and activation of cytotoxic T-lymphocytes (CTLs). This mechanism enables CTLs to recognize and eliminate infected cells and tumor cells. In NK-cells, the presence of CD8A homodimers at the cell surface provides a survival mechanism allowing conjugation and lysis of multiple target cells. CD8A homodimer molecules also promote the survival and differentiation of activated lymphocytes into memory CD8 T-cells.

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