Anti-CD8A Monoclonal Antibody - Amerigo Scientific

Subcat	Description	Isotype	Antibody Modification	Conjugate	Price	Availability
ASPC082	Anti-CD8A Antibody	Mouse IgG2a, Kappa		None	$460	4-6 weeks	Add
ASPC082-1	Anti-CD8A Antibody, Fab fragment	Mouse Fab	His tag	None	$460	In stock	Add
ASPC082-P	Anti-CD8A Antibody, PE	Mouse IgG2a, Kappa		PE	$1,180	2-3 weeks	Add
ASPC082-A	Anti-CD8A Antibody, APC	Mouse IgG2a, Kappa		APC	$980	2-3 weeks	Add
ASPC082-H	Anti-CD8A Antibody, HRP	Mouse IgG2a, Kappa		HRP	$600	2-3 weeks	Add
ASPC082-B	Anti-CD8A Antibody, Biotin	Mouse IgG2a, Kappa		Biotin	$680	2-3 weeks	Add
ASPC082-4	Anti-CD8A Antibody, Fc Silenced	Mouse IgG2a, Kappa	Fc Silenced	None	$980	4-6 weeks	Add

Anti-CD8A Monoclonal Antibody
- Product Description:
  
  The antibody is specific for human CD8. The specific epitope recognized by is within the extracellular domain of the CD8α chain. This antibody is widely used in flow cytometry, immunohistochemistry, and functional assays to identify and sort CD8+ T cells.
  
  Applications:
  
  Functional Assay, Flow Cytometry, Immunofluorescence, Western Blot, Immunoprecipitation
  
  Source:
  
  Mouse
  
  Target:
  
  CD8A
  
  Target Species:
  
  Human
  
  Specificity:
  
  Human CD8a
  
  Immunogen:
  
  Thymocytes from human
  
  Clonality:
  
  Monoclonal
  
  Isotype:
  
  Mouse IgG2a, Kappa
  
  Purification:
  
  The antibody was purified by Protein A.
  
  Purity:
  
  >95% as determined by SDS-PAGE
  
  Aggregation:
  
  <5% as determined by SEC
  
  Concentration:
  
  1 mg/mL
  
  Form:
  
  Liquid
  
  Endotoxin:
  
  Please contact us for more information.
  
  Formulation:
  
  Contact us for customized product form or formulation.
  
  Preservative:
  
  BSA and Azide free.
  
  Stabilizer:
  
  None
  
  Shipping:
  
  Shipped at 4°C.
  
  Storage:
  
  This antibody can be store at 2°C-8°C for one month. Upon delivery aliquot. For longer storage, store at -20°C. Avoid repeated freeze-thaw cycles.
Anti-CD8A Monoclonal Antibody Applications
- Note:
  
  Optimal dilutions/concentrations should be determined by the end user.

Gene Symbol

CD8A

Protein Name

T-cell surface glycoprotein CD8 alpha chain

Molecular Family

CD Molecules

Introduction

The CD8 antigen is a cell surface glycoprotein found on most cytotoxic T lymphocytes that mediates efficient cell-cell interactions within the immune system. The CD8 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class I MHC molecules. The coreceptor functions as either a homodimer composed of two alpha chains or as a heterodimer composed of one alpha and one beta chain. Both alpha and beta chains share significant homology to immunoglobulin variable light chains. This gene encodes the CD8 alpha chain. Multiple transcript variants encoding different isoforms have been found for this gene. The major protein isoforms of this gene differ by the presence or absence of a transmembrane domain and thus differ in being a membrane-anchored or secreted protein.

Alternative Names

CD8a Molecule; T-Lymphocyte Differentiation Antigen T8/Leu-2; T-Cell Surface Glycoprotein CD8 Alpha Chain; CD8 Antigen, Alpha Polypeptide (P32); MAL; Leu2 T-Lymphocyte Antigen; T-Cell Antigen; T-Cell Antigen Leu2;

Gene ID

925

UniProt

P01732

Related Disease

Immunodeficiency 116 (IMD116)

Subcellular Location

Plasma membrane

Tissue Specificity

CD8 on thymus-derived T-cells usually consists of a disulfide-linked alpha/CD8A and a beta/CD8B chain. Less frequently, CD8 can be expressed as a CD8A homodimer. A subset of natural killer cells, memory T-cells, intraepithelial lymphocytes, monocytes and dendritic cells expresses CD8A homodimers. Expressed at the cell surface of plasmacytoid dendritic cells upon herpes simplex virus-1 stimulation.

Cell Type

Dendritic cells, NK cells, T cells, Thymocytes, Tregs

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